Serum brain-derived neurotrophic factor levels in conversion disorder: Comparative study with depression
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Date
2007
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Abstract
The aim of the present study was to compare serum brain-derived neurotrophic factor (BDNF) levels of patients with major depressive disorder (MDD) and conversion disorder (CD). Serum BDNF levels were measured in the following three groups: 15 CD patients without any comorbid diagnosis of psychiatric disorder, 24 patients with MDD, and 26 healthy subjects without any psychiatric diagnosis or psychiatric treatment. The serum BDNF level of the healthy control group (31.4 ± 8.8 ng/mL) was statistically higher than the level of the MDD group (21.2 ± 11.3 ng/mL) and the CD group (24.3 ± 9.0 ng/mL; P = 0.008). This suggests that BDNF level may play a similar role in the pathophysiology of MDD and CD. © 2007 The Authors.
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Keywords
Adolescent , Adult , Biological Markers , Brain-Derived Neurotrophic Factor , Conversion Disorder , Depressive Disorder, Major , Female , Humans , Male , Middle Aged , Personality Inventory , Reference Values , Stress, Psychological , brain derived neurotrophic factor , adult , article , blood level , clinical article , comparative study , controlled study , conversion disorder , enzyme linked immunosorbent assay , female , Hamilton scale , human , major depression , male , pathophysiology , statistical significance