Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations

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dc.contributor.authorOzbilgin, MK
dc.contributor.authorAktas, C
dc.contributor.authorUluer, ET
dc.contributor.authorBuyukuysal, MC
dc.contributor.authorGareveran, MS
dc.contributor.authorKurtman, C
dc.date.accessioned2025-04-10T10:36:27Z
dc.date.available2025-04-10T10:36:27Z
dc.description.abstractOBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.
dc.identifier.issn0884-6812
dc.identifier.urihttp://hdl.handle.net/20.500.14701/42316
dc.language.isoEnglish
dc.titleInfluence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations
dc.typeArticle

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