Development and validation of an analytical methodology based on liquid chromatography-electrospray tandem mass spectrometry for the simultaneous determination of phenolic compounds in olive leaf extract

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dc.contributor.authorCittan M.
dc.contributor.authorÇelik A.
dc.date.accessioned2024-07-22T08:09:56Z
dc.date.available2024-07-22T08:09:56Z
dc.date.issued2018
dc.description.abstractA simple method was validated for the analysis of 31 phenolic compounds using liquid chromatography- electrospray tandem mass spectrometry. Proposed method was successfully applied to the determination of phenolic compounds in an olive leaf extract and 24 compounds were analyzed quantitatively. Olive biophenols were extracted from olive leaves by using microwave-assisted extraction with acceptable recovery values between 78.1 and 108.7%. Good linearities were obtained with correlation coefficients over 0.9916 from calibration curves of the phenolic compounds. The limits of quantifications were from 0.14 to 3.2 μgg-1. Intra-day and inter-day precision studies indicated that the proposed method was repeatable. As a result, it was confirmed that the proposed method was highly reliable for determination of the phenolic species in olive leaf extracts. © The Author(s) 2017.
dc.identifier.DOI-ID10.1093/chromsci/bmy003
dc.identifier.issn00219665
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15006
dc.language.isoEnglish
dc.publisherOxford University Press
dc.rightsAll Open Access; Bronze Open Access
dc.subjectChromatography, Liquid
dc.subjectLinear Models
dc.subjectOlea
dc.subjectPhenols
dc.subjectPlant Extracts
dc.subjectPlant Leaves
dc.subjectReproducibility of Results
dc.subjectSensitivity and Specificity
dc.subjectSpectrometry, Mass, Electrospray Ionization
dc.subjectTandem Mass Spectrometry
dc.subjectphenol derivative
dc.subjectplant extract
dc.subjectchemistry
dc.subjectelectrospray mass spectrometry
dc.subjectliquid chromatography
dc.subjectolive tree
dc.subjectplant leaf
dc.subjectprocedures
dc.subjectreproducibility
dc.subjectsensitivity and specificity
dc.subjectstatistical model
dc.subjecttandem mass spectrometry
dc.titleDevelopment and validation of an analytical methodology based on liquid chromatography-electrospray tandem mass spectrometry for the simultaneous determination of phenolic compounds in olive leaf extract
dc.typeArticle

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