Sleep quality in patients with chronic spontaneous urticaria and relation with Orexin-A, leptin, and ghrelin

Simple item page
dc.contributor.authorGultuna S.
dc.contributor.authorBasa Akdogan B.
dc.contributor.authorGonul M.
dc.contributor.authorAydin F.N.
dc.contributor.authorUnal S.
dc.contributor.authorErkek G.N.
dc.contributor.authorOzalp Ates F.S.
dc.contributor.authorYuceege M.B.
dc.contributor.authorOzdemir S.A.O.
dc.date.accessioned2024-07-22T08:01:06Z
dc.date.available2024-07-22T08:01:06Z
dc.date.issued2024
dc.description.abstractBackground: Sleep can be affected in patients with chronic spontaneous urticaria (CSU). The mechanisms of sleep regulation remain poorly understood. Orexin-A, a neuroexcitatory peptide, plays a role in coordinating sleep-wake states. Ghrelin and leptin are involved in sleep regulation through the orexin system. Objective: The effects of orexin-A, ghrelin, and leptin on sleep quality in patients with CSU have not been investigated. We aimed to determine the effects of CSU on sleep quality and the association between serum orexin-A, ghrelin, and leptin levels, and sleep quality in patients with CSU. Methods: Thirty-three patients with CSU and 34 sex- and age-matched controls were included in the study. Serum orexin-A, leptin, and ghrelin levels, and the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) scores were measured in patients with CSU and in the controls; also used were the chronic urticaria quality-of-life questionnaire score and the urticaria activity score used for 7 consecutive days. Results: Median (minimum-maximum) orexin-A, leptin, and ghrelin levels in patients were 385 pg/mL (90-495 pg/mL), 3.1 ng/mL (0-21.2 ng/mL), and 701.8 pg/mL (101.9-827.7 pg/mL), respectively. Median serum orexin-A and leptin levels were higher in the patients compared with the controls (p < 0.001 and p = 0.012, respectively), whereas the median serum ghrelin levels were similar to the controls (p = 0.616). The serum orexin-A level was positively correlated with ghrelin (r = 0.298, p = 0.014), PSQI sleep quality (r = 0.356, p = 0.003), and ESS (r = 0.357, p = 0.003). Conclusion: Serum orexin-A is associated with sleep quality in patients with CSU. Further studies are needed to elucidate the role of ghrelin and leptin on sleep quality in patients with CSU.
dc.identifier.DOI-ID10.2500/aap.2024.45.240023
dc.identifier.issn15396304
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11325
dc.language.isoEnglish
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectChronic Urticaria
dc.subjectFemale
dc.subjectGhrelin
dc.subjectHumans
dc.subjectLeptin
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOrexins
dc.subjectQuality of Life
dc.subjectSleep Quality
dc.subjectSurveys and Questionnaires
dc.subjectYoung Adult
dc.subjectghrelin
dc.subjectHCRT protein, human
dc.subjectleptin
dc.subjectorexin
dc.subjectadult
dc.subjectblood
dc.subjectcase control study
dc.subjectchronic urticaria
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectquality of life
dc.subjectquestionnaire
dc.subjectsleep quality
dc.subjectyoung adult
dc.titleSleep quality in patients with chronic spontaneous urticaria and relation with Orexin-A, leptin, and ghrelin
dc.typeArticle

Files

Collections

Scopus Koleksiyonu