Effects of esmolol on hemodynamic responses to laryngoscopy and tracheal intubation in diabetic versus non-diabetic patients

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dc.contributor.authorTaşyüz T.
dc.contributor.authorTopçu I.
dc.contributor.authorÖzaslan S.
dc.contributor.authorSakarya M.
dc.date.accessioned2024-07-22T08:22:45Z
dc.date.available2024-07-22T08:22:45Z
dc.date.issued2007
dc.description.abstractAim: We aimed to investigate the efficiency of esmolol, a short-acting β-blocker, in preventing the hemodynamic response to laryngoscopy and endotracheal intubation in diabetic patients. Materials and Methods: Eighty diabetic or non-diabetic patients with ASA physical status I-II scheduled for noncardiac surgery were included in this study. They were divided randomly into 4 groups (Non-diabetic control: NDC, Non-diabetic esmolol: NDE, Diabetic control: DC, Diabetic esmolol: DE). Blood glucose analyses were measured in the preoperative period and at the 10th min of the study. Prior to anesthetic induction, 1 mg/kg esmolol to Groups NDE and DE and saline to Groups NDC and DC were administered in 1 min by slow infusion. After 2 mins, systolic and diastolic arterial blood pressures (SBP, DBP), heart rate (HR), bispectral index (BIS) and peripheral oxygen saturation (SpO2) were recorded in all groups. Laryngoscopy and endotracheal intubation were performed after induction. SBP, DBP, HR, SpO2 and BIS values were recorded every minute during 10 mins after intubation. Results: In Groups NDE and DE, SBP, DBP and HR values were significantly lower after drug administration than the values obtained before drug administration (p<0.05). In Groups NDC, NDE and DC, SBP, DBP and HR values were significantly higher in the first minute of the intubation compared to before drug administration (p<0.05), but were significantly low in subsequent measurements (p<0.05). Blood glucose analyses were found significantly higher in Group NDE than Group NDC (p<0.05). Conclusions: We propose that esmolol might be used effectively to control hemodynamic response to tracheal intubation in diabetic patients. We also determined that esmolol causes no difference in blood glucose levels. © TÜBİTAK.
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19228
dc.language.isoEnglish
dc.subjectAnesthetics
dc.subjectBlood
dc.subjectGlucose
dc.subjectHemodynamics
dc.subjectPatient treatment
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectesmolol
dc.subjectsodium chloride
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbispectral index
dc.subjectcontrolled study
dc.subjectdiabetes control
dc.subjectdiabetes mellitus
dc.subjectdiabetic patient
dc.subjectdrug effect
dc.subjectendotracheal intubation
dc.subjectfemale
dc.subjectheart rate
dc.subjecthemodynamics
dc.subjecthuman
dc.subjectlaryngoscopy
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoxygen saturation
dc.subjectAnesthetic induction
dc.subjectDiabetic patients
dc.subjectDiastolic arterial blood pressures
dc.subjectEndotracheal intubation
dc.subjectEsmolol
dc.subjectLaryngoscopy
dc.subjectMedical problems
dc.titleEffects of esmolol on hemodynamic responses to laryngoscopy and tracheal intubation in diabetic versus non-diabetic patients
dc.typeArticle

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