The Effect of Therapeutic Hypothermia on Prognosis in Patients Receiving Continuous Renal Replacement Therapy

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dc.contributor.authorEvren G.
dc.contributor.authorZengin N.
dc.date.accessioned2024-07-22T08:01:37Z
dc.date.available2024-07-22T08:01:37Z
dc.date.issued2024
dc.description.abstractContinuous renal replacement therapy (CRRT) is a commonly used therapeutic modality in the pediatric intensive care unit (PICU) for the treatment of severe acute kidney injury, as well as for addressing metabolic abnormalities, fluid-electrolyte imbalances, and acid-base disorders. According to reports, therapeutic hypothermia treatment has demonstrated the ability to decrease cellular metabolism, oxygen consumption, formation of free radicals, cell death, and inflammatory signals. The study encompassed all individuals who underwent CRRT at both Manisa City Hospital and Manisa Celal Bayar University Hospital throughout the period from February 2021 to November 2022. A total of 14 patients who received CRRT were subjected to a warming procedure utilizing an external blanket and an external heater attached to the CRRT venous return line, resulting in the attainment of a body temperature exceeding 36̊C. Therapeutic hypothermia was implemented on 12 patients to maintain their body temperature within the range of 32–35̊C. The study population exhibited a median age of 24.5 months, with males comprising 61.5% of the sample. A therapeutic hypothermia treatment was administered to a cohort of 12 patients. The patients who had therapeutic hypothermia exhibited a significantly reduced vasoactive-inotropic score (p = 0.038). Patients who did not receive therapeutic hypothermia exhibited a prolonged need for mechanical ventilation (p = 0.020). The duration of stay in the PICU for patients who underwent therapeutic hypothermia was shown to be considerably shorter compared to those who did not receive therapeutic hypothermia (p = 0.047). The potential efficacy of moderate therapeutic hypothermia appears promising, particularly in the context of patients who are receiving CRRT for severe sepsis and acute respiratory distress syndrome. This is attributed to the anti-inflammatory properties and hypometabolic effects associated with this intervention. To the best of our current understanding, this study represents the initial investigation showcasing the effectiveness of combining therapeutic hypothermia with CRRT in the pediatric population. © Mary Ann Liebert, Inc.
dc.identifier.DOI-ID10.1089/ther.2023.0029
dc.identifier.issn21537658
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11519
dc.language.isoEnglish
dc.publisherMary Ann Liebert Inc.
dc.subjectAcute Kidney Injury
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectContinuous Renal Replacement Therapy
dc.subjectHumans
dc.subjectHypothermia, Induced
dc.subjectIntensive Care Units, Pediatric
dc.subjectMale
dc.subjectPrognosis
dc.subjectRenal Replacement Therapy
dc.subjectRetrospective Studies
dc.subjectfree radical
dc.subjectacute kidney failure
dc.subjectadult respiratory distress syndrome
dc.subjectArticle
dc.subjectartificial ventilation
dc.subjectbody temperature
dc.subjectcell death
dc.subjectcell metabolism
dc.subjectchild
dc.subjectclinical article
dc.subjectcohort analysis
dc.subjectcontinuous renal replacement therapy
dc.subjectcontrolled study
dc.subjectelectrolyte disturbance
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectinotropism
dc.subjectmale
dc.subjectmental capacity
dc.subjectmild hypothermia
dc.subjectoxygen consumption
dc.subjectpediatric intensive care unit
dc.subjectpreschool child
dc.subjectprognosis
dc.subjectrenal replacement therapy
dc.subjectsevere sepsis
dc.subjectuniversity hospital
dc.subjecturban hospital
dc.subjectvenous return
dc.subjectacute kidney failure
dc.subjectinduced hypothermia
dc.subjectprocedures
dc.subjectprognosis
dc.subjectrenal replacement therapy
dc.subjectretrospective study
dc.titleThe Effect of Therapeutic Hypothermia on Prognosis in Patients Receiving Continuous Renal Replacement Therapy
dc.typeArticle

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