The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients
| dc.contributor.author | Yucel, ZPK | |
| dc.contributor.author | Afacan, B | |
| dc.contributor.author | Ilhan, HA | |
| dc.contributor.author | Kose, T | |
| dc.contributor.author | Emingil, G | |
| dc.date.accessioned | 2025-04-10T10:36:06Z | |
| dc.date.available | 2025-04-10T10:36:06Z | |
| dc.description.abstract | Objective This study aimed to investigate the levels of trefoil factor family (TFF)-1, TFF-3 and interleukin (IL)-1 beta in gingival crevicular fluid (GCF), saliva and serum of patients with gingivitis, stage 3 periodontitis and healthy individuals. Materials and Methods A total of 100 individuals consisting of 25 periodontally healthy, 25 gingivitis and 50 stage 3 periodontitis, were enrolled in the study. Clinical periodontal examinations were recorded and GCF, saliva and serum samples were obtained. TFF-1, TFF-3 and IL-1 beta were measured by ELISA. Results TFF-1 and TFF-3 levels in both GCF, saliva and serum were higher in periodontitis patients than healthy controls (p < .001) and gingivitis group (p < .01). The levels of these peptides in all biofluids were similar between gingivitis and healthy control groups (p > .05). GCF, saliva and serum IL-1 beta levels were also higher in periodontitis patients than the controls (p < .01). Periodontitis patients had elevated GCF and saliva IL-beta levels than gingivitis group (p < .001). Conclusion Elevated TFF-1 and TFF-3 levels both locally and systemically in periodontitis in parallel to increased IL-1 beta levels might suggest that these peptides are involved in host response during the periodontal tissue destruction. | |
| dc.identifier.e-issn | 1601-0825 | |
| dc.identifier.issn | 1354-523X | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/42044 | |
| dc.language.iso | English | |
| dc.title | The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients | |
| dc.type | Article |