Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients

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dc.contributor.authorTunc S.E.
dc.contributor.authorAksu K.
dc.contributor.authorKeser G.
dc.contributor.authorOksel F.
dc.contributor.authorDoganavsargil E.
dc.contributor.authorPirildar T.
dc.contributor.authorTurk T.
dc.contributor.authorTerzioglu E.
dc.contributor.authorHuseyinov A.
dc.date.accessioned2024-07-22T08:23:49Z
dc.date.available2024-07-22T08:23:49Z
dc.date.issued2005
dc.description.abstractObjective: The aim of this study was to compare plasma Platelet-activating factor (PAF) and P-selectin (CD62P) activities in Behçet's disease patients with and without thrombosis. Methods: In this cross-sectional and descriptive study, 30 consecutive Behçet's patients were included, 15 of them with venous thrombosis. All patients were also divided into two subgroups according to the presence or absence of clinical activity. Plasma PAF levels, basal and Ca++ ionophore (A23187)-induced leukocyte (cellular) PAF activities, and platelet-rich plasma ΔCD62P activity (the mean fluorescent density difference between CD62P phycoerythrin-positive and -negative stains) were evaluated. Results: In the thrombotic group, plasma PAF (P=0.001), basal leukocyte PAF (P=0.017), induced leukocyte PAF (P=0.024), and ΔCD62P (P=0.023) levels were significantly higher than in the nonthrombotic group. In the whole group of Behçet's patients, there was a positive correlation between plasma PAF and ΔCD62P levels (r=0.533, P=0.002). When we compared clinically active and inactive patients with respect to the above parameters, there was no significant difference, irrespective of thrombosis. Plasma PAF (P=0.001), basal leukocyte PAF (P=0.004), and ΔCD62P (P=0.038) levels were significantly higher in the presence of both clinical activity and thrombosis than of clinical activity alone. Conclusion: Platelet-activating factor and CD62P may contribute to endothelial injury and thrombosis development in Behçet's disease. These two parameters seem related to the presence of thrombosis rather than clinical activity. © Springer-Verlag 2004.
dc.identifier.DOI-ID10.1007/s00296-004-0450-4
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19699
dc.language.isoEnglish
dc.subjectAdult
dc.subjectBehcet Syndrome
dc.subjectCalcimycin
dc.subjectCells, Cultured
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectIonophores
dc.subjectLeukocytes
dc.subjectMale
dc.subjectP-Selectin
dc.subjectPlatelet Activating Factor
dc.subjectVenous Thrombosis
dc.subjectPADGEM protein
dc.subjectthrombocyte activating factor
dc.subjectarticle
dc.subjectBehcet disease
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdeep vein thrombosis
dc.subjectdisease activity
dc.subjectendothelium injury
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectleukocyte
dc.subjectlipid blood level
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectstatistical significance
dc.subjectvein thrombosis
dc.titlePlatelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients
dc.typeArticle

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