Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction

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dc.contributor.authorTaneli F.
dc.contributor.authorYegane S.
dc.contributor.authorUlman C.
dc.contributor.authorTikiz H.
dc.contributor.authorBilge A.R.
dc.contributor.authorAri Z.
dc.contributor.authorUyanik B.S.
dc.date.accessioned2024-07-22T08:23:24Z
dc.date.available2024-07-22T08:23:24Z
dc.date.issued2006
dc.description.abstractLeptin is an adipocytokine that is produced mainly by adipose tissue; it is also identified in atherosclerotic lesions in human coronary atherosclerosis. However, the relation of serum leptin concentrations to ischemic heart disease (IHD) is still obscure. The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations. For this purpose, 35 patients with CSAP, 40 with acute STEMI, and 30 control subjects with normal findings from coronary angiography were taken into the study prospectively. Serum leptin concentrations were significantly higher in patients with CSAP and STEMI compared to the control group (7.74 ± 1.34 vs 6.37 ± 1.85 ng/mL, p = 0.021 and 8.22 ± 3.13 vs 6.37 ± 1.85 ng/mL, p = 0.023, respectively). In addition, serum homocysteine concentrations were significantly increased in patients with CSAP (15.23 ± 5.96 vs 11.40 ± 2.11 μmol/L, p = 0.025) and patients with STEMI (15.90 ±5.02 vs 11.40 ±2.11 μmol/L, p = 0.012) compared to the control group. Serum fibrinogen concentrations were significantly increased only in the CSAP group as compared to controls (4.15 ± 1.39 vs 3.45 ± 1.19 g/L, p = 0.025). No significant correlation was found between leptin levels and selected risk factors. In conclusion, serum leptin concentrations were significantly higher in both the CSAP and STEMI groups. However, owing to the lack of correlation between the leptin levels and selected classical coronary risk factors, it may be considered that leptin can be evaluated as one of the independent risk factors for IHD. Further randomized and controlled studies will be required to determine the pathophysiological meaning of the increased leptin levels and the central role between adipocyte function and atherosclerosis. ©2006 Westminster Publications, Inc.
dc.identifier.DOI-ID10.1177/000331970605700302
dc.identifier.issn00033197
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19517
dc.language.isoEnglish
dc.subjectAngina Pectoris
dc.subjectChronic Disease
dc.subjectElectrocardiography
dc.subjectFemale
dc.subjectFibrinogen
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectLeptin
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.subjectSex Factors
dc.subjectadipocytokine
dc.subjectC reactive protein
dc.subjectcreatine kinase MB
dc.subjectfibrinogen
dc.subjecthomocysteine
dc.subjectleptin
dc.subjectfibrinogen
dc.subjecthomocysteine
dc.subjectleptin
dc.subjectadipocyte
dc.subjectadipose tissue
dc.subjectadult
dc.subjectaged
dc.subjectangiocardiography
dc.subjectarticle
dc.subjectbody mass
dc.subjectcardiovascular risk
dc.subjectcholesterol blood level
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectcoronary artery atherosclerosis
dc.subjectdiabetes mellitus
dc.subjectfemale
dc.subjectheart infarction
dc.subjecthormone blood level
dc.subjecthuman
dc.subjecthypertension
dc.subjectischemic heart disease
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprospective study
dc.subjectrisk factor
dc.subjectserum
dc.subjectsmoking
dc.subjectST segment elevation
dc.subjectstable angina pectoris
dc.subjectangina pectoris
dc.subjectblood
dc.subjectchronic disease
dc.subjectcomparative study
dc.subjectelectrocardiography
dc.subjectheart infarction
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectsex difference
dc.titleIncreased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction
dc.typeArticle

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