Improved efficacy of aerosol delivery to distal airways in pediatric subjects using a new spacer mouth-mask

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dc.contributor.authorYüksel H.
dc.contributor.authorBerardino L.
dc.contributor.authorYüksel D.
dc.contributor.authorYilmaz Ö.
dc.contributor.authorBurak Z.
dc.date.accessioned2024-07-22T08:23:01Z
dc.date.available2024-07-22T08:23:01Z
dc.date.issued2007
dc.description.abstractAerosol nebulization is one of the safest and most effective ways of treating airway diseases especially in children. Failure of inhaled asthma treatment is mainly due to inadequate deposition of drugs in the peripheral area of the lungs. The aim of this study was to compare the efficacy of a traditional mask and that of a new spacer mouth-mask (Nebula, Markos Mefar, Italy) when used with a jet nebulizer, by measuring aerosol deposition in the lungs, oropharynx, upper airways, and gastrointestinal tract. Twelve children without respiratory disease aged between 8 and 13 years were included in the study. Aerosol inhalation was performed using a jet nebulizer with 2 mL of saline solution containing 20 Mci of Tc99m-DTPA. The first group initially performed aerosol inhalation using a traditional facemask and then, one week later, using the new spacer mouth-mask. The second group performed aerosol inhalation using the new spacer mouth-mask first and then, one week later, using a traditional mask. Scintigraphic ventilation images ware then obtained, and aerosol deposition in the trachea, oropharynx, lungs and stomach was measured. In the first group, the radioaerosol deposition in the peripheral lung area using the new spacer mouth-mask was greater 97.8±7.0 vs 68.5*7.9 (p=0.04). On the other hand, the oropharyngeal radioaerosol deposition was greater using the traditional mask: 50.2±5.2 vs 20.3±11.8 (p = 0.028). Similarly, in the second group the peripheral lung deposition was greater and the oropharyngeal deposition was less using the new spacer mouth-mask: 97.3±9.4 vs 70.2*11.2 and 20.7 ± 8.9 vs 46.3±16.8 (p=0.028 and 0.046 respectively). In conclusion, the new design of the spacer mouth-mask allows greater aerosol deposition in the peripheral lung area and less in other parts such as the oropharyngeal area, the central airways and the stomach.
dc.identifier.issn03979148
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19347
dc.language.isoEnglish
dc.subjectAdministration, Inhalation
dc.subjectAdolescent
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectInhalation Spacers
dc.subjectLung
dc.subjectMale
dc.subjectNebulizers and Vaporizers
dc.subjectRadiopharmaceuticals
dc.subjectTechnetium Tc 99m Pentetate
dc.subjectpentetic acid
dc.subjectsodium chloride
dc.subjecttechnetium 99m
dc.subjectaerosol
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug delivery system
dc.subjectdrug dosage form comparison
dc.subjectdrug efficacy
dc.subjecthuman
dc.subjectnebulization
dc.subjectoropharynx
dc.subjectrespiratory tract disease
dc.subjectschool child
dc.subjectscintigraphy
dc.titleImproved efficacy of aerosol delivery to distal airways in pediatric subjects using a new spacer mouth-mask
dc.typeArticle

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