Onosma heterophyllum: Phenolic composition, enzyme inhibitory and antioxidant activities

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dc.contributor.authorOzer M.S.
dc.contributor.authorKirkan B.
dc.contributor.authorSarikurkcu C.
dc.contributor.authorCengiz M.
dc.contributor.authorCeylan O.
dc.contributor.authorAtılgan N.
dc.contributor.authorTepe B.
dc.date.accessioned2024-07-22T08:10:27Z
dc.date.available2024-07-22T08:10:27Z
dc.date.issued2018
dc.description.abstractOnosma species have frequently been used for their colouring and dyeing properties in foods and medicinal preparations. The antioxidant and enzyme inhibitory activities of the ethyl acetate, methanol and water extracts of Onosma heterophyllum (Griseb.) are described. Phytochemical compositions of these extracts were also determined. The water extract showed not only remarkable antioxidant activity in all assays but also considerable inhibitory activity on tyrosinase and α-glucosidase (112.44 μmol KAEs/g dry plant and 984.36 μmol ACEs/g dry plant, respectively). The methanol extract exhibited the highest inhibitory activity on acetylcholinesterase (AChE) and α-amylase (79.18 μmol GALAEs/g dry plant and 10.42 μmol ACEs/g dry plant, respectively). Chromatographic analyses revealed that the water extract was found to be rich in phenolic and flavonoid contents. On the basis of the correlation coefficients calculated separately for all experimental parameter pairs, protocatechuic acid, p-hydroxybenzoic acid, syringic acid, p-coumaric acid and luteolin were found to be highly in correlation with the antioxidant and enzyme inhibitory activities. This study demonstrates that O. heterophyllum, contained in food preparations with various purposes for many years, could be used for the treatment of diabetes as well as its skin whitening effect. © 2017 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.indcrop.2017.10.026
dc.identifier.issn09266690
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15247
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectOnosma
dc.subjectChromatographic analysis
dc.subjectEnzymes
dc.subjectExtraction
dc.subjectMethanol
dc.subjectPlant extracts
dc.subjectAntioxidant activities
dc.subjectDry plants
dc.subjectEnzyme inhibitory
dc.subjectFood preparation
dc.subjectHPLC
dc.subjectInhibitory activity
dc.subjectMethanol extract
dc.subjectOnosma heterophylla
dc.subjectPhenolics
dc.subjectWater extracts
dc.subjectangiosperm
dc.subjectantioxidant
dc.subjectbiochemical composition
dc.subjectconcentration (composition)
dc.subjectdiabetes
dc.subjectenzyme
dc.subjectenzyme activity
dc.subjectherb
dc.subjectinhibitor
dc.subjectliquid chromatography
dc.subjectmethanol
dc.subjectphenolic compound
dc.subjectplant extract
dc.subjectskin
dc.subjectAntioxidants
dc.titleOnosma heterophyllum: Phenolic composition, enzyme inhibitory and antioxidant activities
dc.typeArticle

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