Changes in the plasma activities of protein C and protein S during pregnancy

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dc.contributor.authorOruç S.
dc.contributor.authorSaruç M.
dc.contributor.authorKoyuncu F.M.
dc.contributor.authorÖzdemir E.
dc.date.accessioned2024-07-22T08:25:39Z
dc.date.available2024-07-22T08:25:39Z
dc.date.issued2000
dc.description.abstractThe objective of the study was to determine the changes in the plasma activities of protein C and protein S that occur during normal pregnancy. In this prospective cross-sectional study, plasma activities of protein C and protein S were measured in 32 normal pregnant women in the first, second and third trimester and 6 weeks after delivery. There was a significant fall in protein C and protein S activities during normal pregnancy compared with the post-puerperal period. The activities of protein C and protein S also gradually decreased throughout pregnancy (p < 0.01). Increasing plasma volume during normal pregnancy and its dilutional effect might play some role in the low activities of protein S observed. The normal falls in protein S and protein C activities make it difficult to diagnose protein S and C deficiency during pregnancy. Based on our findings, if a woman has a thromboembolic event during pregnancy, testing for a definitive diagnosis of protein C or protein S deficiency or functional failure should be delayed until at least 6 weeks postpartum.
dc.identifier.DOI-ID10.1111/j.1479-828X.2000.tb01179.x
dc.identifier.issn00048666
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20531
dc.language.isoEnglish
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectPlasma Volume
dc.subjectPostpartum Period
dc.subjectPregnancy
dc.subjectPregnancy Complications, Hematologic
dc.subjectPregnancy Trimester, First
dc.subjectPregnancy Trimester, Second
dc.subjectPregnancy Trimester, Third
dc.subjectProspective Studies
dc.subjectProtein C
dc.subjectProtein C Deficiency
dc.subjectProtein S
dc.subjectProtein S Deficiency
dc.subjectReference Values
dc.subjectReproducibility of Results
dc.subjectThromboembolism
dc.subjectplasma protein
dc.subjectprotein C
dc.subjectprotein S
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdelivery
dc.subjectdiagnostic procedure
dc.subjectdilution
dc.subjectfemale
dc.subjectfirst trimester pregnancy
dc.subjecthuman
dc.subjectplasma volume
dc.subjectpregnancy
dc.subjectprenatal care
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectprotein analysis
dc.subjectprotein deficiency
dc.subjectpuerperium
dc.subjectsecond trimester pregnancy
dc.subjectthird trimester pregnancy
dc.subjectthromboembolism
dc.titleChanges in the plasma activities of protein C and protein S during pregnancy
dc.typeArticle

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