The effect of teicoplanin on fracture healing: An experimental study

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dc.contributor.authorGöçer H.
dc.contributor.authorÖnger M.E.
dc.contributor.authorKuyubaşi N.
dc.contributor.authorÇirakli A.
dc.contributor.authorKir M.Ç.
dc.date.accessioned2024-07-22T08:12:37Z
dc.date.available2024-07-22T08:12:37Z
dc.date.issued2016
dc.description.abstractObjectives: This study aims to investigate the effect of teicoplanin on fracture healing stereologically and histopatologically. Materials and methods: Twenty male Wistar albino rats were separated into two as the study (teicoplanin) and control groups. After intramedullary fixation of the right tibia of all the rats with 0.5 mm Kirschner wire under general anesthesia, standard closed shaft fractures were created using fracture formation apparatus. Teicoplanin (10 mg/kg) and saline were administered intraperitoneally to the study and control groups, respectively. Control radiographs were taken at the end of the procedure and the rats were sacrificed after 28 days. New bone and connective tissue volumes were calculated on obtained tissue samples using unbiased stereological and histopathological techniques. Results: It was observed that teicoplanin increased the formation of bone, vascularization, and connective tissue. There was a statistically significant difference between the two groups in respect of bone and vascular total volume (p<0.05). Although an increase was observed in connective tissue total volume, no statistically significant difference was detected between the two groups (p>0.05). Conclusion: In addition to its antibacterial effect, teicoplanin may increase new bone formation; thus, it may be used safely in the treatment of bone defects accompanied with infection.
dc.identifier.DOI-ID10.5606/ehc.2016.04
dc.identifier.issn13058282
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16127
dc.language.isoEnglish
dc.publisherTurkish Joint Diseases Foundation
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectBone Regeneration
dc.subjectFracture Fixation, Intramedullary
dc.subjectFracture Healing
dc.subjectFractures, Closed
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTeicoplanin
dc.subjectTibia
dc.subjectTreatment Outcome
dc.subjectantiinfective agent
dc.subjectteicoplanin
dc.subjectanimal
dc.subjectbone regeneration
dc.subjectdrug effects
dc.subjectfracture healing
dc.subjectFractures, Closed
dc.subjectintramedullary nailing
dc.subjectmale
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectprocedures
dc.subjectradiography
dc.subjectrat
dc.subjecttibia
dc.subjecttreatment outcome
dc.subjectWistar rat
dc.titleThe effect of teicoplanin on fracture healing: An experimental study
dc.typeArticle

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