The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects

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dc.contributor.authorMavioglu H.
dc.contributor.authorGedizlioglu M.
dc.contributor.authorAkyel S.
dc.contributor.authorAslaner T.
dc.contributor.authorEser E.
dc.date.accessioned2024-07-22T08:23:23Z
dc.date.available2024-07-22T08:23:23Z
dc.date.issued2006
dc.description.abstractObjectives: The cognitive subscale of the Alzheimer's Disease Assesment Scale (ADAS-Cog) is the most widely used test clinical trials dealing with Alzheimer's disease (AD). The aim of this study was to investigate the validity and reliability of the Turkish version of ADAS-Cog. Methods: Twenty-nine patients with AD, fullfilling NINCDS-ADRDA criteria of probable AD, who were in stage 3-5 according to the Global Deterioration Scale (GDS), and 27 non-demented control subjects with similar age, gender and educational status were recruited for the study. The Turkish version of ADAS-Cog, Standardized Mini Mental Status Examination (MMSE) and Short Orientation-Memory-Concentration Test (SOMCT) were applied to both of the groups. Interrater reliability, internal consistency, test-retest reliability; face validity, differential validity and convergent validity were statistically analyzed. Results: Both MMSE and ADAS-Cog have significantly differentiated patients with AD and control subjects (p < 0.001). A significant correlation was established between MMSE and ADAS-Cog scores in AD group (r: -0.739). ADAS-Cog was also highly significantly correlated with GDS (r: 0.720) and SOMCT (r: 0.738). For the group with AD, control and whole cohort coefficients of internal consistency, Cronbach's α: 0.800, 0.515, 0.873 were found respectively. Inter-rater reliability for total ADAS-Cog score was found as ICC: 0.99 and 0.98 and test-retest reliability was found as ICC: 0.91 and 0.95 for demented and nondemented subjects, respectively. Conclusion: The Turkish version of ADAS-Cog has been found to be highly reliable and valid in differentiating patients with mild and moderate AD from nondemented subjects. Copyright © 2006 John Wiley & Sons, Ltd.
dc.identifier.DOI-ID10.1002/gps.1457
dc.identifier.issn10991166
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19505
dc.language.isoEnglish
dc.subjectAged
dc.subjectAlzheimer Disease
dc.subjectCognition Disorders
dc.subjectCross-Cultural Comparison
dc.subjectEducational Status
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectPsychiatric Status Rating Scales
dc.subjectPsychometrics
dc.subjectReproducibility of Results
dc.subjectTurkey
dc.subjectadult
dc.subjectage distribution
dc.subjectaged
dc.subjectAlzheimer disease
dc.subjectarticle
dc.subjectclinical article
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectcorrelation coefficient
dc.subjectdementia
dc.subjectdifferential diagnosis
dc.subjectdisease classification
dc.subjectdisease severity
dc.subjecteducation
dc.subjectface validity
dc.subjectfemale
dc.subjecthuman
dc.subjectinternal consistency
dc.subjectinterrater reliability
dc.subjectmale
dc.subjectmemory
dc.subjectmini mental state examination
dc.subjectneuropsychological test
dc.subjectorientation
dc.subjectrating scale
dc.subjectscoring system
dc.subjectsex difference
dc.subjectstandardization
dc.subjectstatistical analysis
dc.subjectstatistical significance
dc.subjecttest retest reliability
dc.subjectTurkey (republic)
dc.titleThe validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects
dc.typeArticle

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