The role of hydroxytyrosol in health and disease; [Sağlık ve hastalıkta hidroksitirozolün rolü]

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dc.contributor.authorTuğrul B.
dc.contributor.authorOktay L.M.
dc.date.accessioned2024-07-22T08:16:16Z
dc.date.available2024-07-22T08:16:16Z
dc.date.issued2014
dc.description.abstractHydroxytyrosol is a phenolic compound released from the hydrolysis of oleuropein and is present in olive oil, leaf and fruit. Recently, studies on hydroxytyrosol have revealed its strong antioxidant and antiinflamatory effects. In vitro studies conducted in various cancer cell lines and in vivo assays carried out on animals reported strong evidences for its antiinflamatory, antiproliferative and proapoptotic influences. In addition, in cancer it is believed to have inhibitory effects during angiogenesis. Its modulatory role on bone formation and prevention of bone loss has been the attraction of some studies. If the molecular mechanisms and cellular pathways of hydroxytyrosol are elucidated, it will be possible to plan new strategies targeting various disease involved with cancer, inflammatory and cardio-vascular pathologies. In this review, various in vitro and in vivo studies investigating the antioxidant, anticancer, antiinflamatory role of hydroxytyrosol and its inhibitory effects in osteoporosis are discussed. © 2014 Turkish Society for Radiation Oncology.
dc.identifier.DOI-ID10.5505/tjoncol.2014.1095
dc.identifier.issn13007467
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16821
dc.language.isoTurkish
dc.publisherIstanbul Tip Fakultesi
dc.subjecthydroxytyrosol
dc.subjectantiinflammatory activity
dc.subjectantineoplastic activity
dc.subjectantioxidant activity
dc.subjectosteoporosis
dc.subjectReview
dc.titleThe role of hydroxytyrosol in health and disease; [Sağlık ve hastalıkta hidroksitirozolün rolü]
dc.typeReview

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