The FGF signaling pathway and immune system
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2023
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Abstract
The FGF signaling pathway is associated with many physiological events at the cellular level such as wound healing, proliferation, and differentiation, and at the metabolic level such as bone metabolism and endocrine functions, and is associated with pathological events such as cancer, developmental disorders, autoimmune/inflammatory diseases. Therefore, it is one of the important targets in the understanding of homeostasis and the development of new therapeutics. The immune system is roughly the entire body's defence mechanisms against endogenous and exogenous foreign substances. Failure of the immune system to function properly leads to either infections due to immunosuppressive states or autoimmune/ inflammatory diseases due to overactivity. When we look at the studies carried out to date, it is seen that the FGF pathway has important functions in the regulation/dysregulation of the immune system in addition to its many functions in homeostasis. It contributes to the innate and adaptive immune response by affecting both the immune system cells and the structural cells in the surrounding tissues where the immune response occurs. In addition, it is an important signaling pathway worth investigating due to its role in the pathogenesis of some immune system-related diseases as well as in autoimmune/inflammatory/allergic events. This chapter focuses on the role of the FGF pathway in immunological events. © 2023 Nova Science Publishers, Inc. All rights reserved.