Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum

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dc.contributor.authorKirkan B.
dc.contributor.authorSarikurkcu C.
dc.contributor.authorOzer M.S.
dc.contributor.authorCengiz M.
dc.contributor.authorAtılgan N.
dc.contributor.authorCeylan O.
dc.contributor.authorTepe B.
dc.date.accessioned2024-07-22T08:09:26Z
dc.date.available2024-07-22T08:09:26Z
dc.date.issued2018
dc.description.abstractThis study focused on phytochemical characterization and biological evaluation, both antioxidant and enzymatic inhibition, of ethyl acetate (OTT-EtOAc), methanol (OTT-MeOH), and water (OTT-W) extracts from Onosma tauricum var. tauricum aerial parts. The OTT-W extract was found to be the richest one in terms of its phenolic and flavonoid contents. Amounts of the phenolic and flavonoid compounds were determined as 40.88 μmol GAEs/g and 7.40 μmol REs/g dry plant (dp), respectively. The OTT-MeOH and OTT-W extracts were also found to contain significant amounts of chlorogenic acid, rosmarinic acid, p-hydroxybenzoic acid, caffeic acid, rutin, p-coumaric acid, trans-cinnamic acid, luteolin, and apigenin. The OTT-W extract showed remarkable antioxidant activity in phosphomolybdenum, ferrous ion chelating, reducing power, and radical scavenging assays. The OTT-MeOH extract exhibited inhibitory activity on acetylcholinesterase (AChE) (54.62 μmol GALAEs/g dp), while the extracts remained almost inactive on butyrylcholinesterase (BChE). The OTT-W extract also exhibited inhibitory activity on tyrosinase (90.66 μmol KAEs/g dp) and α-glucosidase (2258.87 μmol ACEs/g dp). The results suggest that especially the OTT-MeOH and OTT-W extracts can be used as a source of alternative natural products in the treatment of diseases caused by the enzymes evaluated here. © 2018 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.indcrop.2018.09.043
dc.identifier.issn09266690
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14821
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectBoraginaceae
dc.subjectOnosma
dc.subjectAntennas
dc.subjectAntioxidants
dc.subjectEnzyme activity
dc.subjectFlavonoids
dc.subjectFree radicals
dc.subjectValue engineering
dc.subjectAnti-oxidant activities
dc.subjectChlorogenic acids
dc.subjectInhibitory activity
dc.subjectOnosma tauricum var. tauricum (Boraginaceae)
dc.subjectPhenolic composition
dc.subjectacetate
dc.subjectantioxidant
dc.subjectdicotyledon
dc.subjectenzyme activity
dc.subjectinhibition
dc.subjectinhibitor
dc.subjectmethanol
dc.subjectphenolic compound
dc.subjectphytochemistry
dc.subjectpigment
dc.subjectplant extract
dc.subjectExtraction
dc.titlePhenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum
dc.typeArticle

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