Effects of adenosine A1 receptor agonist CCPA and antagonist DPCPX on ischemia/reperfusion-induced arrhythmias in rats; [Sıçanlarda, adenozin agonisti, CCPA, ve antagonisti DPCPX'in iskemi/reperfüzyon ile uyarılan aritmiler üzerine etkisi]

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dc.contributor.authorBozdoǧan O.
dc.contributor.authorGonca E.
dc.contributor.authorEkerbiçer N.
dc.date.accessioned2024-07-22T08:21:14Z
dc.date.available2024-07-22T08:21:14Z
dc.date.issued2010
dc.description.abstractAim: Adenosine has been commonly used to treat supraventricular tachycardia in clinics. However, there are only a few studies on the effects of adenosine on ischemia or reperfusion induced arrhythmia and they conflict with the results of the present study. During this study, we aimed to clarify the effect of adenosine on ischemia-reperfusion induced arrhythmia. Materials and methods: Left coronary artery was ligated for 6 min and it was released for 15 min to produce reperfusion. A1 adenosine agonist CCPA (2 Chloro-N6 - Cyclopentyl-adenosine), and A1 selective antagonist DPCPX (8 - Cyclopentyl-1,3-dipropylxanthine) in 5 μg/kg dose alone and in combination were given intravenously before ligation, at the second minute of the ligation and just following the reperfusion. Results: Adenosine given only at the second minute of the ligation is found to decrease the total duration of arrhythmia observed in the reperfusion stage. DPCPX given in this period is found to block the antiarrhythmic effect of adenosine. Adenosine given after reperfusion and before ligation was not effective in decreasing reperfusion induced arrhythmia. Conclusion: The time dependent effect of the administration during ischemia and reperfusion was important for the effect of adenosine. The present study showed that antiarrhythmia produced by adenosine is related to the activation of A1 adenosine receptor. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-0808-8
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18519
dc.language.isoTurkish
dc.publisherTurkiye Klinikleri Journal of Medical Sciences
dc.rightsAll Open Access; Bronze Open Access
dc.subjectBiomedical engineering
dc.subjectMedicine
dc.subject2 chloro 6 n cyclopentyladenosine
dc.subject8 cyclopentyl 1,3 dipropylxanthine
dc.subjectadenosine
dc.subjectadenosine A1 receptor
dc.subjectAdenosine
dc.subjectArrhythmias
dc.subjectIschemia
dc.subjectIschemia reperfusion
dc.subjectLeft coronary arteries
dc.subjectReperfusion
dc.subjectSupraventricular tachycardias
dc.subjectTime-dependent effects
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectheart arrhythmia
dc.subjectheart muscle ischemia
dc.subjectleft coronary artery
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectreperfusion injury
dc.subjecttreatment response
dc.subjectDiseases
dc.titleEffects of adenosine A1 receptor agonist CCPA and antagonist DPCPX on ischemia/reperfusion-induced arrhythmias in rats; [Sıçanlarda, adenozin agonisti, CCPA, ve antagonisti DPCPX'in iskemi/reperfüzyon ile uyarılan aritmiler üzerine etkisi]
dc.typeArticle

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