In vitro Anti-Leishmanial Activity of Essential Oils Extracted from Plants Growing in Northern Cyprus Against Leishmania tropica; [Kuzey Kıbrıs’ta Yetişen Bitkilerden Elde Edilen Uçucu Yağlarda Leishmania tropica’ya Karşı in vitro Anti-leishmanial Etkinlik Araştırılması]

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dc.contributor.authorGüler E.
dc.contributor.authorÖzbilgin A.
dc.contributor.authorÇavuş İ.
dc.contributor.authorBaddal B.
dc.contributor.authorEtikan İ.
dc.contributor.authorHüsnü Can Başer K.
dc.contributor.authorŞanlıdağ T.
dc.date.accessioned2024-07-22T08:05:59Z
dc.date.available2024-07-22T08:05:59Z
dc.date.issued2021
dc.description.abstractObjective: Natural plant products are considered as a source of novel and effective compounds for the treatment of leishmaniasis. In this study, the in vitro activities of essential oils obtained from Origanum dubium (OD), Origanum majorana (OM), Salvia fruticosa (SF) and Laurus nobilis (LN) plants in Northern Cyprus were investigated against Leishmania tropica. Methods: Leishmania tropica strain (MHOM/TR/2012/CBCL-LT) was obtained. RPMI-1640 was added to 96-well plates in 100 µL aliquots, 100 µg/mL essential oil was added to the first well of each row and serial 2-fold dilutions were performed. A promastigote suspension was pipetted into all wells, and the plates were incubated. The promastigotes were enumerated using a haemocytometer. Results: OD essential oil was effective at killing all promastigotes at a minimum inhibitor height (MIC)=0.2 μg/mL and had high activity at the lowest concentrations. Both SF and LN oils had MIC=1.56 μg/mL and LD50 =0.78 μg/mL. SF was observed to impair promastigote morphology at the lowest concentrations, while LN did not exert any effect at concentrations <0.2 μg/mL. OM essential oil was found to have a MIC=3.13 μg/mL and a LD50 =1.56 μg/mL. Conclusion: All tested essential oils inhibited promastigotes of Leishmania tropica. OD essential oil demonstrated the highest anti-leishmanial activity. © 2021 Turkish Society for Parasitology.
dc.identifier.DOI-ID10.4274/tpd.galenos.2021.6888
dc.identifier.issn13006320
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13336
dc.language.isoTurkish
dc.publisherGalenos Publishing House
dc.rightsAll Open Access; Gold Open Access
dc.subjectAntiprotozoal Agents
dc.subjectCyprus
dc.subjectLaurus
dc.subjectLeishmania tropica
dc.subjectLeishmaniasis
dc.subjectLethal Dose 50
dc.subjectOils, Volatile
dc.subjectOriganum
dc.subjectParasitic Sensitivity Tests
dc.subjectPlant Extracts
dc.subjectPlant Oils
dc.subjectSalvia
dc.subjectantiprotozoal agent
dc.subjectessential oil
dc.subjectplant extract
dc.subjectvegetable oil
dc.subjectchemistry
dc.subjectCyprus
dc.subjectdrug effect
dc.subjectdrug sensitivity
dc.subjectisolation and purification
dc.subjectLaurus
dc.subjectLD50
dc.subjectLeishmania tropica
dc.subjectleishmaniasis
dc.subjectOriganum
dc.subjectparasitology
dc.subjectSalvia
dc.titleIn vitro Anti-Leishmanial Activity of Essential Oils Extracted from Plants Growing in Northern Cyprus Against Leishmania tropica; [Kuzey Kıbrıs’ta Yetişen Bitkilerden Elde Edilen Uçucu Yağlarda Leishmania tropica’ya Karşı in vitro Anti-leishmanial Etkinlik Araştırılması]
dc.typeArticle

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