The role of water-soluble meconium subfraction and lipid-soluble meconium subfraction on the superior mesenteric artery vasoconstriction in chick embryos

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dc.contributor.authorŞiyve S.
dc.contributor.authorUlusoy O.
dc.contributor.authorKarakuş O.Z.
dc.contributor.authorMurat N.
dc.contributor.authorUslu M.E.
dc.contributor.authorAteş O.
dc.contributor.authorHakgüder G.
dc.contributor.authorOlguner M.
dc.contributor.authorAkgür F.M.
dc.date.accessioned2024-07-22T08:10:59Z
dc.date.available2024-07-22T08:10:59Z
dc.date.issued2017
dc.description.abstractObjective Intraamniotic meconium has been responsible for intestinal damage in gastroschisis and meconium-dependent intestinal ischemia has been proposed to induce additional intestinal damage in gastroschisis. This study is aimed to determine the effects of lipid and water-soluble meconium subfractions on the contractility of the superior mesenteric artery (SMA). Materials and methods The study was conducted on 18-day fertilized chick embryos (Gallus Domesticus). Meconium is fractioned into water and lipid-soluble components. Only one SMA tissue was prepared from each embryo and suspended in the organ bath. Isometric contraction responses (ICR) were created in SMA tissues by one hour of incubation in Krebs–Henseleit solution for each group. Groups consisted of control, meconium, water-soluble meconium subfraction and lipid-soluble meconium subfraction. ICR of the SMA specimens were evaluated with a transducer-amplifier system on a computer. The data were expressed (mean ± 1SD) as milliNewton (mN). Results The ICR of the meconium, water-soluble meconium subfraction and lipid-soluble meconium subfraction groups were significantly high when compared to the control group (p < 0.01). The meconium and water-soluble meconium subfraction created more contraction response than the lipid-soluble meconium subfraction (p < 0.01). The ICR of the meconium group was not different from the ICR of the water-soluble meconium subfraction group (p > 0.05). Conclusion Water-soluble meconium subfraction has a profound vasoconstrictor effect on the SMA compared to the lipid-soluble meconium subfraction. © 2016 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.jpedsurg.2016.09.066
dc.identifier.issn00223468
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15471
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.subjectAnimals
dc.subjectChick Embryo
dc.subjectGastroschisis
dc.subjectGlucose
dc.subjectIntestinal Diseases
dc.subjectIntestines
dc.subjectLipids
dc.subjectMeconium
dc.subjectMesenteric Artery, Superior
dc.subjectTromethamine
dc.subjectVasoconstriction
dc.subjectWater
dc.subjectglucose
dc.subjectKrebs-Henseleit solution
dc.subjectlipid
dc.subjecttrometamol
dc.subjectwater
dc.subjectanimal tissue
dc.subjectartery constriction
dc.subjectArticle
dc.subjectblood vessel parameters
dc.subjectchick embryo
dc.subjectchicken
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectembryo
dc.subjectintestine injury
dc.subjectintestine ischemia
dc.subjectisometric contraction response
dc.subjectlipid soluble meconium
dc.subjectmeconium
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsmall intestine
dc.subjectsuperior mesenteric artery
dc.subjectwater soluble meconium
dc.subjectanimal
dc.subjectchemistry
dc.subjectcomplication
dc.subjectgastroschisis
dc.subjectIntestinal Diseases
dc.subjectintestine
dc.subjectmeconium
dc.subjectpathophysiology
dc.subjectsuperior mesenteric artery
dc.subjectvasoconstriction
dc.titleThe role of water-soluble meconium subfraction and lipid-soluble meconium subfraction on the superior mesenteric artery vasoconstriction in chick embryos
dc.typeArticle

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