Thyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat hearts

Simple item page
dc.contributor.authorKosova F.
dc.contributor.authorAltan N.
dc.contributor.authorSepici A.
dc.contributor.authorEngin A.
dc.contributor.authorKocamanoglu N.
dc.date.accessioned2024-07-22T08:18:35Z
dc.date.available2024-07-22T08:18:35Z
dc.date.issued2013
dc.description.abstractFree radicals, oxidative stress, and antioxidants have become commonly used terms in modern discussion of disease mechanisms. Accumulation of evidence suggests that toxic oxygen-derived reactive free radicals (superoxide, peroxide and hydroxyl radicals) play a crucial role in etiology of diabetes and its complication. Thus, it was aimed to determine the role of thyroid hormones in reversal of antioxidatant enzyme activities and lipid peroxidation alterations observed in experimentally induced diabetic rat hearts. The present study investigates the antioxidant enzyme activities such as SOD, CAT, GSH-Px and lipid peroxidation products in cardiac tissues of streptozotosin (STZ)-induced diabetic rats before and after thyroidectomy. Our results showed that CAT, GPx enzyme activities and FOX, MDA levels were increased (p<0.05) and SOD, Mn-SOD, Cu-SOD activities were decreased (p<0.05) during diabetes, hypothyroidism and hypothyroidism with diabetes, which can be regulated in different percentages with treatment of insulin and various doses of thyroid hormone (p<0.05). In conclusion, in this study, the possible contribution of thyroid hormones to the insulin effect of normalizing the induced diabetic changes in cardiac tissue and serum of rat has been seen.
dc.identifier.DOI-ID10.4149/BLL_2013_039
dc.identifier.issn13360345
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17367
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCatalase
dc.subjectDiabetes Mellitus, Experimental
dc.subjectGlutathione Peroxidase
dc.subjectInsulin
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectMyocardium
dc.subjectRats
dc.subjectSuperoxide Dismutase
dc.subjectThyroid Hormones
dc.subjectThyroidectomy
dc.subjectantioxidant
dc.subjectcatalase
dc.subjectglutathione peroxidase
dc.subjectinsulin
dc.subjectmalonaldehyde
dc.subjectsuperoxide dismutase
dc.subjectthyroid hormone
dc.subjectanimal
dc.subjectarticle
dc.subjectenzymology
dc.subjectexperimental diabetes mellitus
dc.subjectheart muscle
dc.subjectmale
dc.subjectmetabolism
dc.subjectrat
dc.subjectthyroidectomy
dc.titleThyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat hearts
dc.typeArticle

Files

Collections

Scopus Koleksiyonu