Comparison of 18F-FDG PET/CT findings with current clinical disease status in patients with takayasu's arteritis

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dc.contributor.authorKarapolat I.
dc.contributor.authorKalfa M.
dc.contributor.authorKeser G.
dc.contributor.authorYalçin M.
dc.contributor.authorInal V.
dc.contributor.authorKumanlioǧlu K.
dc.contributor.authorPirildar T.
dc.contributor.authorAksu K.
dc.date.accessioned2024-07-22T08:18:30Z
dc.date.available2024-07-22T08:18:30Z
dc.date.issued2013
dc.description.abstractObjective. 18F-fluorodeoxyglucosepositron emission tomography/computed tomography (18F-FDG PET/CT) scanning has been proposed as a new tool to assess disease activity in Takayasu arteritis (TA). We investigated whether 18F-FDG PET/CT findings were consistent with current clinical disease status in patients with TA. Methods. In this cross sectional study, 22 patients with TA were enrolled. Clinical disease activity was assessed by the combination of National Institutes of Health (NIH) criteria, Disease Extent Index-Takayasu (DEI-Tak) score, physician global assessment and 18F-FDG PET/CT scans. Results. At the time 18F-FDG PET/CT scans were taken, the majority of the patients (17/22) were using immunosuppressive (IS) drugs, and only four patients had clinically active disease. 18F-FDG PET/CT scans confirmed the presence of active vasculitic lesions in those four patients. In 16 out of 18 patients who were accepted to be in clinical remission, 18F-FDG PET/ CT scans were also normal. There were only two patients with discordant results, i.e. active 18F-FDG PET/CT findings despite the lack of clinical activity. Interestingly, clinical exacerbation occurred four weeks later in one of them. Overall sensitivity and specificity of 18F-FDG PET/CT findings for clinical activity were 100% and 88.9%, respectively. Conclusion. We found that 18F-FDG PET/CT findings were generally consistent with clinical disease status in TA. Although use of IS drugs certainly impairs diagnostic accuracy of 18FFDG PET/CT in TA, this imaging method may still have a potential for confirming remission or detecting disease activity in patients with TA receiving treatment. © CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2013.
dc.identifier.issn1593098X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17333
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAdult
dc.subjectChi-Square Distribution
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectFluorodeoxyglucose F18
dc.subjectHumans
dc.subjectImmunosuppressive Agents
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPositron-Emission Tomography and Computed Tomography
dc.subjectPredictive Value of Tests
dc.subjectRadiopharmaceuticals
dc.subjectRecurrence
dc.subjectRemission Induction
dc.subjectSensitivity and Specificity
dc.subjectSeverity of Illness Index
dc.subjectTakayasu Arteritis
dc.subjectTime Factors
dc.subjectTomography, X-Ray Computed
dc.subjectTreatment Outcome
dc.subjectYoung Adult
dc.subjectfluorodeoxyglucose f 18
dc.subjectimmunosuppressive agent
dc.subjectdiagnostic agent
dc.subjectradiopharmaceutical agent
dc.subjectadult
dc.subjectaorta arch syndrome
dc.subjectarticle
dc.subjectclinical article
dc.subjectclinical assessment
dc.subjectcomputer assisted emission tomography
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic test accuracy study
dc.subjectdisease activity
dc.subjectdisease exacerbation
dc.subjectDisease Extent Index-Takayasu score
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectnamed inventories, questionnaires and rating scales
dc.subjectNational Institutes of Health criteria
dc.subjectPET scanner
dc.subjectpriority journal
dc.subjectremission
dc.subjectsensitivity and specificity
dc.subjectadolescent
dc.subjectaorta arch syndrome
dc.subjectchi square distribution
dc.subjectcomparative study
dc.subjectcomputer assisted tomography
dc.subjectmiddle aged
dc.subjectpredictive value
dc.subjectradiography
dc.subjectrecurrent disease
dc.subjectscintiscanning
dc.subjectseverity of illness index
dc.subjecttime
dc.subjecttreatment outcome
dc.titleComparison of 18F-FDG PET/CT findings with current clinical disease status in patients with takayasu's arteritis
dc.typeArticle

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