Neuroprotective effects of MK-801 against traumatic brain injury in immature rats

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dc.contributor.authorSönmez A.
dc.contributor.authorSayin O.
dc.contributor.authorGürgen S.G.
dc.contributor.authorÇalişir M.
dc.date.accessioned2024-07-22T08:13:32Z
dc.date.available2024-07-22T08:13:32Z
dc.date.issued2015
dc.description.abstractTraumatic brain injury (TBI) is a major health problem in pediatric ages and also has major social, economic, and emotional outcomes, with diverse sequelae in many spheres of everyday life. We aimed to investigate the effect of MK-801, a competitive NMDA receptor antagonist, on hippocampal damage and behavioral deficits on 10-day-old rat pups subjected to contusion injury. The aims of the present study were to determine: (i) the short term effects of MK-801 on hippocampal BDNF, NGF and NMDA receptor immunoreactivity and neuron density in hippocampus (ii) long term effects of MK-801 on cognitive dysfunction following TBI in the immature rats. MK-801, was injected intraperitoneally at the doses of 1. mg/kg of body weight immediately after induction of traumatic injury. Hippocampal damage was examined by cresyl violet staining, BDNF, NGF and NMDAR receptor immunohistochemistry on P10 day and behavioral alterations were evaluated using elevated plus maze and novel object recognition tests two months after the trauma. Histopathological and immunohistochemical evaluations showed that treatment with a single dose of 1. mg/kg MK-801 (i.p.) significantly ameliorated the trauma induced hippocampal neuron loss and decreased BDNF, NGF and NMDAR expressions in CA1, CA3 and DG hippocampal brain regions. Additionally, treatment with MK-801 ameliorated anxiety and hippocampus dependent memory of animals subjected to trauma. These results show that acute treatment of MK-801 has a neuroprotective role against trauma induced hippocampal neuron loss and associated cognitive impairment in immature rats. © 2015 Elsevier Ireland Ltd.
dc.identifier.DOI-ID10.1016/j.neulet.2015.05.001
dc.identifier.issn03043940
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16362
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectAnimals
dc.subjectBrain Injuries
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectCognition Disorders
dc.subjectDizocilpine Maleate
dc.subjectHippocampus
dc.subjectMemory
dc.subjectN-Methylaspartate
dc.subjectNerve Growth Factor
dc.subjectNeurons
dc.subjectNeuroprotective Agents
dc.subjectRats, Wistar
dc.subjectbrain derived neurotrophic factor
dc.subjectdizocilpine
dc.subjectn methyl dextro aspartic acid receptor
dc.subjectnerve growth factor
dc.subjectbrain derived neurotrophic factor
dc.subjectdizocilpine maleate
dc.subjectn methylaspartic acid
dc.subjectnerve growth factor
dc.subjectneuroprotective agent
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectanxiety
dc.subjectapoptosis
dc.subjectArticle
dc.subjectbehavior disorder
dc.subjectbrain damage
dc.subjectcell density
dc.subjectcognitive defect
dc.subjectcontrolled study
dc.subjectdentate gyrus
dc.subjectexploratory behavior
dc.subjecthippocampus
dc.subjectimmunoreactivity
dc.subjectmemory
dc.subjectmemory disorder
dc.subjectnerve cell
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectnovel object recognition test
dc.subjectpriority journal
dc.subjectrat
dc.subjectstratum pyramidale
dc.subjecttraumatic brain injury
dc.subjectanimal
dc.subjectBrain Injuries
dc.subjectCognition Disorders
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectpathology
dc.subjectpsychology
dc.subjectWistar rat
dc.titleNeuroprotective effects of MK-801 against traumatic brain injury in immature rats
dc.typeArticle

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