Changes in optical coherence tomography angiography measures throughout the day: Diurnal variation or test-retest variability?

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dc.contributor.authorTekin Altinbay B.
dc.contributor.authorKurt E.
dc.contributor.authorAltinisik M.
dc.date.accessioned2024-07-22T08:01:28Z
dc.date.available2024-07-22T08:01:28Z
dc.date.issued2024
dc.description.abstractPurpose:To evaluate the repeatability and diurnal variation of the retinal vessel density and foveal avascular zone parameters using optical coherence tomography angiography.Methods:Forty-one healthy individuals were measured twice in the morning and once in the evening. Foveal avascular zone area, perimetry, foveal density; superficial and deep capillary plexus (superficial capillary plexus, deep capillary plexus) vessel density, and central macular thickness were evaluated with the intraclass correlation coefficient, coefficient of repeatability, and Bland-Altman plots.Results:Repeatability was evaluated with two consecutive scans taken in the morning. The coefficient of repeatabilities (%) was 5.4; 4.3, and 8.8 for the foveal avascular zone area, perimetry, and foveal density, respectively, with excellent intraclass correlation coefficients. Intraclass correlation coefficient was poor for parafovea (0.33), whereas excellent for fovea (0.97) in superficial capillary plexus-vessel density. Coefficient of repeatability for fovea and parafovea was 19.19% and 10.43%, respectively. Intraclass correlation coefficient values were poor (0.3-0.4) with 10% to 16% measurement differences in deep capillary plexus-vessel density parameters. Coefficient of repeatabilities for central macular thickness was between 1% and 2% with excellent intraclass correlation coefficient. The analysis on diurnal variation yielded comparable results.Conclusion:Except for the parafoveal vessel density, optical coherence tomography angiography is a highly reproducible device for measuring foveal avascular zone and vessel density using 6 × 6 scans with undilated pupils. However, variation in optical coherence tomography angiography parameters observed throughout the day could be attributed to test-retest variation rather than diurnal rhythm. © 2024 Lippincott Williams and Wilkins. All rights reserved.
dc.identifier.DOI-ID10.1097/IAE.0000000000004020
dc.identifier.issn0275004X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11470
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectCircadian Rhythm
dc.subjectFluorescein Angiography
dc.subjectFovea Centralis
dc.subjectHumans
dc.subjectMacula Lutea
dc.subjectRetinal Vessels
dc.subjectTomography, Optical Coherence
dc.subjectarticle
dc.subjectblood vessel density
dc.subjectcentral macular thickness
dc.subjectcircadian rhythm
dc.subjectcorrelation coefficient
dc.subjectdiagnosis
dc.subjectfemale
dc.subjectfoveal avascular zone
dc.subjecthuman
dc.subjectmacular thickness
dc.subjectmale
dc.subjectoptical coherence tomography angiography
dc.subjectoptics
dc.subjectperimetry
dc.subjectpupil
dc.subjectretina blood vessel
dc.subjectcircadian rhythm
dc.subjectfluorescence angiography
dc.subjectoptical coherence tomography
dc.subjectprocedures
dc.subjectretina fovea
dc.subjectretina macula lutea
dc.subjectvascularization
dc.titleChanges in optical coherence tomography angiography measures throughout the day: Diurnal variation or test-retest variability?
dc.typeArticle

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