Comparison of the desmoplastic reaction and invading ability in invasive ductal carcinoma of the breast and prostatic adenocarcinoma based on the expression of heat shock protein 47 and fascin

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dc.contributor.authorNese N.
dc.contributor.authorKandiloglu A.R.
dc.contributor.authorSimsek G.
dc.contributor.authorLekili M.
dc.contributor.authorOzdamar A.
dc.contributor.authorCatalkaya A.
dc.contributor.authorCoskun T.
dc.date.accessioned2024-07-22T08:21:04Z
dc.date.available2024-07-22T08:21:04Z
dc.date.issued2010
dc.description.abstractOBJECTIVE: To investigate the diversity within invasive ductal carcinoma (IDC) and prostatic adenocarcinoma (PCa) by evaluating immunohistochemical expression of heat shock protein 47 (HSP47) and fascin, the molecules that are related to desmoplasia and invasion, and analyze its correlation with clinicopathologic parameters. STUDY DESIGN: HSP47 and fascin immunoreactivity (IR) was evaluated in 49 mastectomies diagnosed as IDC and 57 radical prostatectomies diagnosed as PCa. IR was evaluated as: 0: < 5%, 1+: 5-25%, 2+: 25-50%, 3+: >50%. RESULTS: HSP47 and fascin were localized to cytoplasm, and HSP47 and fascin IR were higher in IDC and PCa than benign groups (p<0.05). HSP47 IR in neoplastic cells was 42.1% and 28.6%, in stroma was 81.6% and 15.8% in IDC and PCa, respectively; fascin IR in neoplastic cells was 65.3% in IDC and 15.8% in PCa. Fascin expression correlated with estrogen receptor and progesterone receptor negativity, tumor size and stage in IDC and surgical margin status in PCa. HSP47 expression correlated bilaterality in PCa. HSP47 positively correlated with survival in IDC. CONCLUSION: HSP47 and fascin expression may play role in the pathogenesis of IDC and PCa because their expression is significantly higher in IDC and PCa than their normal counterpart. Although there is no relationship with recurrence or metastatic status, fascin overexpression correlated with tumor size, which may prompt its use as a prognostic factor in IDC. © Science Printers and Publishers, Inc.
dc.identifier.issn08846812
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18451
dc.language.isoEnglish
dc.subjectAdenocarcinoma
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBreast Neoplasms
dc.subjectCarcinoma, Ductal, Breast
dc.subjectCarrier Proteins
dc.subjectFemale
dc.subjectHSP47 Heat-Shock Proteins
dc.subjectHumans
dc.subjectImmunoenzyme Techniques
dc.subjectMale
dc.subjectMastectomy
dc.subjectMicrofilament Proteins
dc.subjectMiddle Aged
dc.subjectNeoplasm Staging
dc.subjectProstatectomy
dc.subjectProstatic Neoplasms
dc.subjectSurvival Rate
dc.subjectTumor Markers, Biological
dc.subjectYoung Adult
dc.subjectestrogen receptor
dc.subjectfascin
dc.subjectheat shock protein 47
dc.subjectprogesterone receptor
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcancer invasion
dc.subjectcancer staging
dc.subjectcancer survival
dc.subjectcellular distribution
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunoreactivity
dc.subjectintraductal carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpriority journal
dc.subjectprostate adenocarcinoma
dc.subjectprotein expression
dc.subjecttumor volume
dc.titleComparison of the desmoplastic reaction and invading ability in invasive ductal carcinoma of the breast and prostatic adenocarcinoma based on the expression of heat shock protein 47 and fascin
dc.typeArticle

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