Sleep quality in patients with chronic spontaneous urticaria and relation with Orexin-A, leptin, and ghrelin

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dc.contributor.authorGultuna, S
dc.contributor.authorAkdogan, BB
dc.contributor.authorGonul, M
dc.contributor.authorAydin, FN
dc.contributor.authorUnal, S
dc.contributor.authorErkek, GN
dc.contributor.authorAtes, FSO
dc.contributor.authorYuceege, MB
dc.contributor.authorOzdemir, SAO
dc.date.accessioned2025-04-10T10:35:28Z
dc.date.available2025-04-10T10:35:28Z
dc.description.abstractBackground: Sleep can be affected in patients with chronic spontaneous urticaria (CSU). The mechanisms of sleep regulation remain poorly understood. Orexin-A, a neuroexcitatory peptide, plays a role in coordinating sleep-wake states. Ghrelin and leptin are involved in sleep regulation through the orexin system. Objective: The effects of orexin-A, ghrelin, and leptin on sleep quality in patients with CSU have not been investigated. We aimed to determine the effects of CSU on sleep quality and the association between serum orexin-A, ghrelin, and leptin levels, and sleep quality in patients with CSU. Methods: Thirty-three patients with CSU and 34 sex- and age-matched controls were included in the study. Serum orexin-A, leptin, and ghrelin levels, and the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) scores were measured in patients with CSU and in the controls; also used were the chronic urticaria quality-of-life questionnaire score and the urticaria activity score used for 7 consecutive days. Results: Median (minimum-maximum) orexin-A, leptin, and ghrelin levels in patients were 385 pg/mL (90-495 pg/mL), 3.1 ng/mL (0-21.2 ng/mL), and 701.8 pg/mL (101.9-827.7 pg/mL), respectively. Median serum orexin-A and leptin levels were higher in the patients compared with the controls (p <0.001 and p = 0.012, respectively), whereas the median serum ghrelin levels were similar to the controls (p = 0.616). The serum orexin-A level was positively correlated with ghrelin (r = 0.298, p = 0.014), PSQI sleep quality (r = 0.356, p = 0.003), and ESS (r = 0.357, p = 0.003). Conclusion: Serum orexin-A is associated with sleep quality in patients with CSU. Further studies are needed to elucidate the role of ghrelin and leptin on sleep quality in patients with CSU.
dc.identifier.e-issn1539-6304
dc.identifier.issn1088-5412
dc.identifier.urihttp://hdl.handle.net/20.500.14701/41478
dc.language.isoEnglish
dc.titleSleep quality in patients with chronic spontaneous urticaria and relation with Orexin-A, leptin, and ghrelin
dc.typeArticle

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