Flow Behavior and Drug Release Study of Injectable Pluronic F-127 Hydrogels containing Bioactive Glass and Carbon-Based Nanopowders

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dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorTürk M.
dc.date.accessioned2024-07-22T08:07:38Z
dc.date.available2024-07-22T08:07:38Z
dc.date.issued2020
dc.description.abstractInjectable biomaterials have gained significant attention in recent years since they can be delivered to the defect sites through minimally-invasive approaches. In this work, thermo-responsive injectable hydrogels containing borate-based bioactive glass particles and carbon-based nanopowders were designed for bone tissue engineering applications. For this purpose, mixtures of Pluronic F127 block-copolymer and 13-93B3 bioactive glass particles with different sizes (2.3 µm, 14 µm, 150 µm) were prepared in aqueous medium and their in situ gelation were investigated through rheological measurements as a function of temperature. Effects of graphene nanopowders and multi-walled carbon nanotubes on the flow behavior of the designed hydrogel system were also investigated. Results revealed that viscosity of the prepared hydrogel system was strongly dependent on the temperature and the bioactive glass particle size. Inclusion of graphene and multi-walled carbon nanotubes in this system caused a further increase in viscosity. All of the hydrogel compositions designed in the study showed shear thinning flow behavior which is a crucial parameter for injectability. Drug release studies showed that the addition of bioactive glass and carbon-based nanoparticles improved the drug release behavior of the prepared hydrogels. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10904-019-01346-2
dc.identifier.issn15741443
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14040
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectBioactive glass
dc.subjectBlock copolymers
dc.subjectCarbon nanotubes
dc.subjectControlled drug delivery
dc.subjectGelation
dc.subjectGraphene
dc.subjectHydrogels
dc.subjectNanotubes
dc.subjectParticle size
dc.subjectShear flow
dc.subjectShear thinning
dc.subjectTargeted drug delivery
dc.subjectTissue engineering
dc.subjectBone tissue engineering
dc.subjectDrug release study
dc.subjectHydrogel composition
dc.subjectInjectable biomaterials
dc.subjectInjectable hydrogels
dc.subjectPluronic F-127
dc.subjectRheological measurements
dc.subjectShear thinning flow
dc.subjectMultiwalled carbon nanotubes (MWCN)
dc.titleFlow Behavior and Drug Release Study of Injectable Pluronic F-127 Hydrogels containing Bioactive Glass and Carbon-Based Nanopowders
dc.typeArticle

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