The association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women - A hyperinsulinemic euglycemic insulin clamp study

Simple item page
dc.contributor.authorSaruç M.
dc.contributor.authorYüceyar H.
dc.contributor.authorAyhan S.
dc.contributor.authorTürkel N.
dc.contributor.authorTuzcuoglu I.
dc.contributor.authorCan M.
dc.date.accessioned2024-07-22T08:24:46Z
dc.date.available2024-07-22T08:24:46Z
dc.date.issued2003
dc.description.abstractBackground/Aims: The relationship between insulin resistance and the occurrence of fatty acid has been documented. Recently DHEA (dehydroepiandrosterone) was shown to have a protective effect against development of fatty liver in rats. We aimed to investigate the association of nonalcoholic fatty liver and serum levels of DHEA, obesity, fat distribution and insulin resistance and to evaluate the effect of DHEA on fatty liver, obesity and insulin resistance. Methodology: Thirteen postmenopausal women with nonalcoholic fatty liver and 14 postmenopausal women with normal liver histology were included into the study. Body mass index, waist-hip ratio, serum DHEA, DHEAS, triglyceride, cholesterol levels and insulin resistance were determined. Fatty liver was determined by ultrasound and established by liver biopsy and histology. Hyperinsulinemic euglycemic clamp studies were performed. Results: The subjects in both groups were age matched (p>0.05). Body mass index showed obesity in patients with fatty liver but not in control group (p=0.01). Central obesity was present in women with fatty liver (p=0.039). As expected, insulin resistance was significantly present in patients with fatty liver (p=0.001). DHEA and DHEAS levels of women with fatty liver were greater than those of control group (p1=0.001 and p2=0.0001, respectively). DHEA and DHEAS were positively correlated with both body mass index and waist-hip ratio. However, glucose disposal rate was inversely and significantly correlated with DHEA and DHEAS levels. Conclusions: These data do not support the hypothesis that DHEA or DHEAS protect postmenopausal women against fatty liver, diabetes and obesity. Indeed, DHEA and DHEAS may be the cause of fatty liver, obesity (especially abdominal obesity) and diabetes in estrogen-deficient women.
dc.identifier.issn01726390
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20122
dc.language.isoEnglish
dc.subjectBlood Glucose
dc.subjectBody Composition
dc.subjectBody Constitution
dc.subjectBody Mass Index
dc.subjectCholesterol
dc.subjectClimacteric
dc.subjectDehydroepiandrosterone
dc.subjectDehydroepiandrosterone Sulfate
dc.subjectFatty Liver
dc.subjectFemale
dc.subjectHumans
dc.subjectHyperinsulinism
dc.subjectInsulin Resistance
dc.subjectLiver
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectTriglycerides
dc.subjectcholesterol
dc.subjectglucose
dc.subjectinsulin
dc.subjectprasterone
dc.subjectprasterone sulfate
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectanthropometric parameters
dc.subjectarticle
dc.subjectbody fat
dc.subjectbody mass
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectdisease association
dc.subjectfatty liver
dc.subjectfemale
dc.subjectglucose metabolism
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthyperinsulinemia
dc.subjectinsulin resistance
dc.subjectliver biopsy
dc.subjectliver disease
dc.subjectobesity
dc.subjectpostmenopause
dc.subjectpriority journal
dc.subjectwaist hip ratio
dc.titleThe association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women - A hyperinsulinemic euglycemic insulin clamp study
dc.typeArticle

Files

Collections

Scopus Koleksiyonu