Anaphylaxis in Turkish children: A multi-centre, retrospective, case study

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dc.contributor.authorOrhan F.
dc.contributor.authorCanitez Y.
dc.contributor.authorBakirtas A.
dc.contributor.authorYilmaz O.
dc.contributor.authorBoz A.B.
dc.contributor.authorCan D.
dc.contributor.authorKuyucu S.
dc.contributor.authorHarmanci K.
dc.contributor.authorTahan F.
dc.contributor.authorReisli I.
dc.contributor.authorKarakas T.
dc.contributor.authorBaki A.
dc.contributor.authorCokugras H.
dc.contributor.authorCakir M.
dc.contributor.authorYuksel H.
dc.date.accessioned2024-07-22T08:19:56Z
dc.date.available2024-07-22T08:19:56Z
dc.date.issued2011
dc.description.abstractBackground: Anaphylaxis is a serious and potentially lethal systemic reaction affecting more than one organ or system. Objective: We aimed to describe the demographic characteristics, clinical features, causes, settings, and administered therapy in Turkish children. Methods: This retrospective, case note study included all children referred to the outpatient clinics of the Pediatric Allergy Departments of the participating study centres from 1 July 1999 to 30 June 2009 for investigation of anaphylaxis or who were seen by us at the moment of the reaction during the same period and who met the clinical criteria of anaphylaxis. Results: Two hundred and twenty-four cases of anaphylaxis were reported in 137 children (88 boys, P = 0.0001). The mean ± SD age at the referral was 7.7 ± 4.2 years (range: 4 months-17 years). Ninety-eight episodes (43.8%) occurred at home. The symptoms were cutaneous in 222 (99.1%) episodes, respiratory in 217 (96.9%), neuro-psychiatric in 118 (52.7%), cardiovascular in 92 (41.1%), and gastrointestinal in 88 (39.3%). Biphasic reaction was reported in seven episodes (3.1%, 95% CI: 1.5-6.3). Death occurred in one case (0.4%, 95% CI: 0.08-2.4). Treatment was available in 158 episodes (70.5%). Of them, 148 (93.7%) received antihistamines, 132 (83.5%) corticosteroids, 51 (32.3%) epinephrine, and 17 (10.8%) beta-2-mimetics. The causative agents were foods in 86 (38.4%) episodes, hymenoptera venom in 84 (37.5%), drugs and medications in 47 (21.0%), and latex in 5 (2.2%). In two episodes (0.9%), the causative agent was unidentified. Allergy to the trigger was known prior to anaphylaxis in 116 (51.8%) episodes. An epinephrine auto-injector had been prescribed for 70 children (51.1%). Conclusions and Clinical Relevance: Anaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first-line treatment of anaphylaxis, was administered in only a third of the children. © 2011 Blackwell Publishing Ltd.
dc.identifier.DOI-ID10.1111/j.1365-2222.2011.03859.x
dc.identifier.issn13652222
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17909
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAnaphylaxis
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectRecurrence
dc.subjectRetrospective Studies
dc.subjectTurkey
dc.subjectadrenalin
dc.subjectantihistaminic agent
dc.subjectcorticosteroid
dc.subjectHymenoptera venom
dc.subjectlatex
dc.subjectadolescent
dc.subjectallergy
dc.subjectanaphylaxis
dc.subjectarticle
dc.subjectbeta adrenergic stimulation
dc.subjectcardiovascular symptom
dc.subjectchild
dc.subjectconfidence interval
dc.subjectdemography
dc.subjectfemale
dc.subjectgastrointestinal symptom
dc.subjecthuman
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnewborn
dc.subjectpopulation based case control study
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectschool child
dc.subjectTurkey (republic)
dc.titleAnaphylaxis in Turkish children: A multi-centre, retrospective, case study
dc.typeArticle

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