Fabrication and characterization of poly(ε-caprolactone) coated silicate and borate-based bioactive glass composite scaffolds

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dc.contributor.authorDeliormanli A.M.
dc.date.accessioned2024-07-22T08:12:10Z
dc.date.available2024-07-22T08:12:10Z
dc.date.issued2016
dc.description.abstractIn this study, silicate 13-93 and borate based 13-93B3 bioactive glass scaffolds with high porosity and interconnected pore structure (pore size 100-500 μm) were prepared by foam replication method. In order to improve the mechanical properties, the scaffolds were coated and infiltrated with a poly(ε-caprolactone) (PCL) solution at different concentrations (5, 10, and 20 wt%). Results revealed that the mechanical properties of the scaffolds were significantly improved by the PCL coating. The addition of 10% PCL coating led to approximately 10-fold increase of compressive strength in comparison with noncoated scaffolds. The bioactivity of scaffolds upon immersion in simulated body fluid was maintained in the PCL-coated scaffolds at all concentrations; however, a decrease in the formation rate and amount of crystalline hydroxyapatite was observed as the PCL concentration was increased in the coating layer. Degradation rate of the borate-based bioactive glass scaffolds was tailored by the PCL coating. It is concluded that the fabricated bioactive composite scaffolds represent promising candidates for bone tissue engineering applications. © SAGE Publications.
dc.identifier.DOI-ID10.1177/0021998315583320
dc.identifier.issn00219983
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15949
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.subjectBiomechanics
dc.subjectCoatings
dc.subjectCompressive strength
dc.subjectDegradation
dc.subjectMechanical properties
dc.subjectPlastic coatings
dc.subjectPore size
dc.subjectScaffolds
dc.subjectScaffolds (biology)
dc.subjectSilicates
dc.subjectTissue
dc.subjectTissue engineering
dc.subjectBone tissue engineering
dc.subjectCrystalline hydroxyapatite
dc.subjectFabrication and characterizations
dc.subjectInterconnected pores
dc.subjectPoly (epsiloncaprolactone)
dc.subjectPolymer Coating
dc.subjectSimulated body fluids
dc.subjectTissue engineering applications
dc.subjectBioactive glass
dc.titleFabrication and characterization of poly(ε-caprolactone) coated silicate and borate-based bioactive glass composite scaffolds
dc.typeArticle

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