The effect of testosterone treatment on urodynamic findings and histopathomorphology of pelvic floor muscles in female rats with experimentally induced stress urinary incontinence

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dc.contributor.authorMammadov R.
dc.contributor.authorSimsir A.
dc.contributor.authorTuglu I.
dc.contributor.authorEvren V.
dc.contributor.authorGurer E.
dc.contributor.authorÖzyurt C.
dc.date.accessioned2024-07-22T08:19:56Z
dc.date.available2024-07-22T08:19:56Z
dc.date.issued2011
dc.description.abstractObjective In recent studies, it has been observed that androgen receptors are densely located in pelvic floor muscles. We aimed to investigate the effect of testosterone on urodynamic findings and histopathomorphology of pelvic floor muscles in rats with experimentally induced stress urinary incontinence. Materials and methods Twenty-eight adult female rats were randomized into four groups. Group I: rats in which SUI was induced and single-dose testosterone was administered 30 days later, group II: rats in which SUI was induced and single-dose testosterone was administered within the same session, group III: rats in which SUI was induced and saline was injected intramuscularly 30 days later, and group IV: the sham group. In order to demonstrate objectively the curative and preventive role of testosterone in experimental model of SUI, urodynamic examination and histopathomorphological evaluation of levator ani muscle were performed. Results Myofiber areas in groups I and II were detected to be significantly larger than those of the control group (P<0.001). Another parameter was leak point pressure value by urodynamy. Regarding this parameter, LPP values in groups 1, 2 and 4 were observed to be significantly higher than those of group 3 (P<0.001). The results of the comparison among groups 1, 2 and 4 revealed no significance (P>0.05), which indicates that testosterone provides continence in a similar way to the group in which sciatic nerve section was not performed. Conclusions In the present study, it has been demonstrated that testosterone has both preventive and curative effects on rat models of experimental SUI. © 2011 Springer Science+Business Media, B.V.
dc.identifier.DOI-ID10.1007/s11255-011-9938-5
dc.identifier.issn15732584
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17914
dc.language.isoEnglish
dc.subjectAndrogens
dc.subjectAnimals
dc.subjectFemale
dc.subjectMuscle Fibers, Skeletal
dc.subjectMuscle, Skeletal
dc.subjectPelvic Floor
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSciatic Nerve
dc.subjectTestosterone
dc.subjectUrinary Incontinence, Stress
dc.subjectUrodynamics
dc.subjecttestosterone undecanoate
dc.subjectandrogen
dc.subjecttestosterone
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectfemale
dc.subjectmorphometrics
dc.subjectmuscle cell
dc.subjectnonhuman
dc.subjectpelvis floor
dc.subjectprophylaxis
dc.subjectrandomized controlled trial
dc.subjectrat
dc.subjectsciatic nerve
dc.subjectsingle drug dose
dc.subjectstress incontinence
dc.subjecttreatment response
dc.subjecturodynamics
dc.subjectanimal
dc.subjectdrug effect
dc.subjectinnervation
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectpelvis floor
dc.subjectsciatic nerve
dc.subjectskeletal muscle
dc.subjectSprague Dawley rat
dc.titleThe effect of testosterone treatment on urodynamic findings and histopathomorphology of pelvic floor muscles in female rats with experimentally induced stress urinary incontinence
dc.typeArticle

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