Analysis of the association of chronic spontaneous urticaria with interlekin-4, -10, transforming growth factor-b1, interferon-γ, interleukin-17A and -23 by autologous serum skin test

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dc.contributor.authorDegirmenci P.B.
dc.contributor.authorKrmaz C.
dc.contributor.authorVatansever S.
dc.contributor.authorOnur E.
dc.contributor.authorNal E.
dc.contributor.authorErdin S.
dc.contributor.authorOzyurt B.
dc.date.accessioned2024-07-22T08:10:54Z
dc.date.available2024-07-22T08:10:54Z
dc.date.issued2017
dc.description.abstractAim: To contribute to the understanding of the pathogenesis of chronic spontaneous urticaria (CSU) by identifying its relationship with autoimmunity and cytokines using the autologous serum skin test (ASST) and peripheral blood mononuclear cell culture (PBMC) method. Material and methods: Interleukins (IL)-4, IL-10, transforming growth factor (TGF-1), interferon (IFN)-γ, IL-17A, and IL-23 levels in cell supernatants obtained by the PBMC method were measured using ELISA. Disease activity was assessed by determining the urticaria activity score (UAS). Results: A total of 40 patients diagnosed with CSU participated in this study. Twenty patients had positive ASST results, and 20 had negative results. The control group included 20 healthy volunteers. We found that the IL-23 (p = 0.01), IL-10 (p = 0.04) and IL-4 (p = 0.04) levels of the patient groups were significantly lower compared with those of the control group. The IL-23 (p = 0.009), IL-10 (p = 0.009), IL-4 (p = 0.001), and IL-17 (p = 0.05) levels of the ASST(-) patient group were significantly lower compared with those of the control group. In addition, the IL-4 (p = 0.03) and IFN-γ (p = 0.05) levels of the ASST(+) patient group were significantly lower compared with those of the control group, and the ASST(+) patients had a significantly higher UAS than the ASST(-) patients (p = 0.021). Conclusions: These results, when considered together with current reports in the literature, indicate that immune dysregulation occurs in the pathogenesis of CSU, causing cytokine imbalance.
dc.identifier.DOI-ID10.5114/pdia.2016.57679
dc.identifier.issn1642395X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15436
dc.language.isoEnglish
dc.publisherTermedia Publishing House Ltd.
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectgamma interferon
dc.subjectinterleukin 10
dc.subjectinterleukin 17
dc.subjectinterleukin 23
dc.subjectinterleukin 4
dc.subjecttransforming growth factor beta1
dc.subjectadult
dc.subjectArticle
dc.subjectautoimmunity
dc.subjectautologous serum skin test
dc.subjectchronic spontaneous urticaria
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdisease activity
dc.subjectdisease association
dc.subjectdisease marker
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmolecular dynamics
dc.subjectmolecular pathology
dc.subjectprotein determination
dc.subjectprotein function
dc.subjectscoring system
dc.subjectskin test
dc.subjecturticaria
dc.titleAnalysis of the association of chronic spontaneous urticaria with interlekin-4, -10, transforming growth factor-b1, interferon-γ, interleukin-17A and -23 by autologous serum skin test
dc.typeArticle

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