Investigation of the cochlear effects of intratympanic steroids administered following acoustic trauma

Simple item page
dc.contributor.authorOzdogan F.
dc.contributor.authorEnsari S.
dc.contributor.authorCakir O.
dc.contributor.authorOzcan K.M.
dc.contributor.authorKoseoglu S.
dc.contributor.authorOzdas T.
dc.contributor.authorGurgen S.G.
dc.contributor.authorDere H.
dc.date.accessioned2024-07-22T08:19:34Z
dc.date.available2024-07-22T08:19:34Z
dc.date.issued2012
dc.description.abstractObjectives/Hypothesis: To electrophysiologically and histomorphologically demonstrate the effects of intratympanic corticosteroids administered following an acoustic trauma on cochlear hair cells. Methods: The trial was performed on 16 Wistar albino rats. The rats underwent distortion product otoacoustic emissions (DPOAE) measurement before the acoustic trauma, and subsequently rats were exposed to noise. Following acoustic trauma, the otoacoustic emission measurement was repeated. The rats were divided into two groups, a study group and a control group. The study rats were injected with methylprednisolone via the intratympanic route throughout the study. In the control group, the rats were injected daily with saline. After performing repeated otoacoustic emission measurements, one rat in each of the groups was sacrificed and their cochleae isolated. Results: The histological investigation performed after the 1st week revealed a statistically significantly higher rate of apoptotic cells in the inner and particularly the outer hair cells of the rat cochleae in the control group compared to the study group. Early measurement of DPOAE within the 1st week demonstrated significantly better amplitudes in the study group compared to controls. The otoacoustic emission assessment performed on the 14th day demonstrated statistically similar DPOAE values between the two groups. Conclusions: Intratympanic methylprednisolone injection administered following an acoustic trauma appears to reduce cochlear outer hair cell loss. The impact on hearing loss is less certain. Early measurement of DPOAE within the 1st week shows significantly better amplitudes in the study group compared to controls. However at 2 weeks, there is no statistically significant difference in DPOAE amplitudes between the study and control group. © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
dc.identifier.DOI-ID10.1002/lary.23185
dc.identifier.issn15314995
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17748
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectCochlea
dc.subjectDisease Models, Animal
dc.subjectFollow-Up Studies
dc.subjectGlucocorticoids
dc.subjectHearing Loss, Noise-Induced
dc.subjectInjections
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTympanic Membrane
dc.subjectmethylprednisolone
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectbasilar membrane
dc.subjectcell loss
dc.subjectcochlea
dc.subjectcochlea spiral canal
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcorticosteroid therapy
dc.subjectdistortion product otoacoustic emission
dc.subjectdrug efficacy
dc.subjectelectrophysiology
dc.subjectexternal ear
dc.subjecthair cell
dc.subjecthearing loss
dc.subjectinner ear
dc.subjectmale
dc.subjectnoise injury
dc.subjectnonhuman
dc.subjectotoscopy
dc.subjectpriority journal
dc.subjectrat
dc.subjectspiral ligament
dc.subjectwhite noise
dc.titleInvestigation of the cochlear effects of intratympanic steroids administered following acoustic trauma
dc.typeArticle

Files

Collections

Scopus Koleksiyonu