The Factor v G1691A, Factor v H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease

Simple item page
dc.contributor.authorÇiftdoǧan D.Y.
dc.contributor.authorCoşkun Ş.
dc.contributor.authorUlman C.
dc.contributor.authorTkz H.
dc.date.accessioned2024-07-22T08:21:33Z
dc.date.available2024-07-22T08:21:33Z
dc.date.issued2009
dc.description.abstractAtherosclerosis, the major cause of coronary artery disease (CAD), has a very long asymptomatic development phase, which begins in childhood. In this study, we describe the Factor V G1691A, Factor V H1299R and prothrombin G20210A gene polymorphisms in children with a family history of premature CAD. Evidence of these polymorphisms in these children may predict the probability of having atherosclerosis in the future. Our study included a total of 140 children, 72 males and 68 females between the ages of 4.9 and 15.7 years. Among these children, 73 had a parental history of premature CAD and the remaining 67 belonged to our control group. The participants were screened for the mutations Factor V G1691A, Factor V H1299R and prothrombin G20210A by polymerase chain reaction amplified DNA products with specific oligonucleotide probes. Our results suggested that frequencies of the mutated allele of Factor V G1691A and prothrombin G20210A are higher in children with a parental history of premature CAD. In conclusion, Factor V G1691A and prothrombin G20210A polymorphisms which were detected in higher frequencies in children with a parental history of premature CAD may indicate a risk for developing atherosclerosis and might be useful in screening for CAD in children; however, large population-based research is necessary to investigate further genetic risk assessment for CAD. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
dc.identifier.DOI-ID10.1097/MCA.0b013e32832bdb8c
dc.identifier.issn09546928
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18669
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAge of Onset
dc.subjectAtherosclerosis
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCoronary Artery Disease
dc.subjectFactor V
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectMale
dc.subjectMutation
dc.subjectPedigree
dc.subjectPolymorphism, Genetic
dc.subjectProthrombin
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectalanine
dc.subjectarginine
dc.subjectblood clotting factor 5
dc.subjectDNA
dc.subjectglycine
dc.subjecthistidine
dc.subjectprothrombin
dc.subjectadolescent
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectchild
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectfamily history
dc.subjectfemale
dc.subjectgene amplification
dc.subjectgene frequency
dc.subjectgenetic polymorphism
dc.subjectgenetic risk
dc.subjectgenetic screening
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmutational analysis
dc.subjectoligonucleotide probe
dc.subjectparent
dc.subjectpolymerase chain reaction
dc.subjectprediction
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectprobability
dc.subjectrisk assessment
dc.subjectschool child
dc.titleThe Factor v G1691A, Factor v H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease
dc.typeArticle

Files

Collections

Scopus Koleksiyonu