Synthesis and Anticancer Activities of Amide-Bridged Coumarin-Quinazolinone Hybrid Compounds
| dc.contributor.author | Caliskan, N | |
| dc.contributor.author | Mentese, E | |
| dc.contributor.author | Yilmaz, F | |
| dc.contributor.author | Ilhan, MS | |
| dc.date.accessioned | 2025-04-10T10:34:06Z | |
| dc.date.available | 2025-04-10T10:34:06Z | |
| dc.description.abstract | Some novel 3-aminoquinazolin-4(3H)-one derivatives were synthesized by the reaction of 2-aminobenzhydrazide and corresponding iminoester hydrochlorides and then reacted with coumarin-3-carbonyl chloride to obtain novel coumarin-quinazolinone hybrids. The synthesized hybrid compounds were screened for their anticancer activity against various human cancer and normal cell lines. N-{2-[(4-Bromo- and N-{2-[(3-bromo-phenyl)methyl]-4-oxoquinazolin-3(4H)-yl}-2-oxo-2H-1-benzopyran-3-carboxamides exhibited the highest cytotoxic effect on the PC-3 prostate cancer cell line: IC50 35.3 +/- 0.6 and 36.8 +/- 0.8 mu g/L, respectively. N-{2-[(4-Fluoro-, N-{2-[(4-bromo-, and N-{2-[(3,4-dichloro-phenyl)methyl]-4-oxoquinazolin-3(4H)-yl}-2-oxo-2H-1-benzopyran-3-carboxamides showed the highest activity against the MCF-7 breast cancer cell line: IC50 48.5 +/- 0.4, 44.8 +/- 0.4 and 46.1 +/- 0.5 mu g/L, respectively. | |
| dc.identifier.e-issn | 1608-3393 | |
| dc.identifier.issn | 1070-4280 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/40317 | |
| dc.language.iso | English | |
| dc.title | Synthesis and Anticancer Activities of Amide-Bridged Coumarin-Quinazolinone Hybrid Compounds | |
| dc.type | Article |