JNK/FOXO may be key mechanistic pathway for the hormetic anti-aging

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dc.contributor.authorErol A.
dc.date.accessioned2024-07-22T08:23:02Z
dc.date.available2024-07-22T08:23:02Z
dc.date.issued2007
dc.description.abstractFOXO transcription factors and evolutionarily conserved c-jun N-terminal kinase (JNK) could hold the key to counteract hormetic anti-aging and common diseases. Hormesis is increasingly recognized as a mechanism underlying the beneficial anti-aging effects of certain genetic and environmental factors. Caloric restriction and exercise increase the resistance of organisms to stress and activate stress resistance pathways in cells in different tissues throughout the body by hormesis based mechanism. JNK triggers the relocalization of FOXO factors to the nucleus inducing the expression of FOXO dependent stress response and damage repairing genes. This adaptive response to stress stimuli may play an important role in regulating homeostasis at the organismal level and contribute to longevity.
dc.identifier.DOI-ID10.1016/j.mehy.2006.09.022
dc.identifier.issn03069877
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19358
dc.language.isoEnglish
dc.subjectAging
dc.subjectCell Aging
dc.subjectEvolution
dc.subjectForkhead Transcription Factors
dc.subjectHumans
dc.subjectJNK Mitogen-Activated Protein Kinases
dc.subjectLongevity
dc.subjectModels, Biological
dc.subjectOxidative Stress
dc.subjectSignal Transduction
dc.subjectchaperone
dc.subjectpolydeoxyribonucleotide synthase
dc.subjectreactive oxygen metabolite
dc.subjectstress activated protein kinase
dc.subjecttranscription factor FKHR
dc.subjecttranscription factor FKHRL1
dc.subjecttranscription factor FOXO
dc.subjectaging
dc.subjectcaloric restriction
dc.subjectcell level
dc.subjectenvironmental factor
dc.subjectexercise
dc.subjecthemodynamics
dc.subjectheredity
dc.subjecthomeostasis
dc.subjecthormesis
dc.subjectletter
dc.subjectlifespan
dc.subjectmetabolic stress
dc.subjectoxidative stress
dc.subjectpleiotropy
dc.subjectpriority journal
dc.subjectsurvival
dc.subjecttemperature stress
dc.subjectupregulation
dc.titleJNK/FOXO may be key mechanistic pathway for the hormetic anti-aging
dc.typeLetter

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