Insulin sensitivity indices: Fasting versus glucose-stimulated ýndices in pediatric non-alcoholic fatty liver disease

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dc.contributor.authorOzhan B.
dc.contributor.authorErsoy B.
dc.contributor.authorKiremitci S.
dc.contributor.authorOzkol M.
dc.contributor.authorTaneli F.
dc.date.accessioned2024-07-22T08:13:45Z
dc.date.available2024-07-22T08:13:45Z
dc.date.issued2015
dc.description.abstractOBJECTIVE: We aimed to compare insulin sensitivity indices, fasting vs glucose stimulated, in children and adolescents with non-alcoholic fatty liver disease. PATIENTS AND METHODS: Two hundredeleven obese children with median age of 11.24 ± 2.65 years were evaluated. After initial clinical and anthropometric examination, B-mode ultrasonography (USG) was performed and all subjects underwent Oral Glucose Tolerance Test (OGTT). Quantitative insulin sensitivity check index (QUICKI), homeostatic model assessment for insulin resistance (Homa-IR), the insulinogenic index (IGI), the Matsuda index, and the oral glucose insulin sensitivity (OGIS) model were used to determine peripheral insulin sensitivity. RESULTS: 59.24% (68 boys, 57 girls) of obese children had NALFD. The prevalence of FLD in obese adolescents was significantly higher than in prepubertal children (65.8% vs. 51.5%). Fasting glucose, insulin, Homa-IR, QUICKI, and OGIS and Matsuda were significantly different between subjects with and without NALFD. Insulin and glucose indices were not found to be significantly different in the prepubertal group, whereas Homa-IR, QUICKI, Matsuda, and OGIS were significantly different in the pubertal group. Age, waist circumference, and OUICKI were found to be risk factors associated with the presence of NALFD in the logistic-regression analysis. CONCLUSIONS: Age, waist circumference, and OUICKI were found to be risk factors associated with NALFD. As the value of QUICKI decreases, the probability of having steatosis increases. Although OGTT results gave the information about the glucose tolerance of a subject, indices derived from OGTT were not found to be superior to the traditional surrogates such as Homa-IR or QUICKI.
dc.identifier.issn11283602
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16396
dc.language.isoEnglish
dc.publisherVerduci Editore
dc.subjectBlood Glucose
dc.subjectChild
dc.subjectFasting
dc.subjectFemale
dc.subjectGlucose
dc.subjectHumans
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectNon-alcoholic Fatty Liver Disease
dc.subjectObesity
dc.subjectRisk Factors
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectglucose
dc.subjectinsulin
dc.subjecttriacylglycerol
dc.subjectglucose
dc.subjectglucose blood level
dc.subjectinsulin
dc.subjectadolescent
dc.subjectage
dc.subjectArticle
dc.subjectbody height
dc.subjectbody mass
dc.subjectbody weight
dc.subjectchild
dc.subjectchildhood disease
dc.subjectchildhood obesity
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectdisorders of carbohydrate metabolism
dc.subjectechography
dc.subjectfatty liver
dc.subjectfemale
dc.subjectgroups by age
dc.subjecthomeostatic model assessment for insulin resistance
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectinsulin sensitivity
dc.subjectinsulin sensitivity index
dc.subjectinsulinogenic index
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectMatsuda index
dc.subjectmetabolic parameters
dc.subjectnonalcoholic fatty liver
dc.subjectoral glucose insulin sensitivity model
dc.subjectoral glucose tolerance test
dc.subjectprevalence
dc.subjectQuantitative Insulin Sensitivity Check Index
dc.subjectrisk factor
dc.subjectschool child
dc.subjectwaist circumference
dc.subjectanalysis
dc.subjectblood
dc.subjectdiet restriction
dc.subjectglucose blood level
dc.subjectinsulin resistance
dc.subjectmetabolism
dc.subjectnonalcoholic fatty liver
dc.subjectobesity
dc.titleInsulin sensitivity indices: Fasting versus glucose-stimulated ýndices in pediatric non-alcoholic fatty liver disease
dc.typeArticle

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