The effect of very low dose pulsed magnetic waves on cochlea; [Efeito de ondas magnéticas pulsadas de dosagem extremamente baixa na cóclea]

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dc.contributor.authorTuhanioğlu B.
dc.contributor.authorErkan S.O.
dc.contributor.authorGürgen S.G.
dc.contributor.authorÖzdaş T.
dc.contributor.authorGörgülü O.
dc.contributor.authorÇiçek F.
dc.contributor.authorGünay İ.
dc.date.accessioned2024-07-22T08:08:50Z
dc.date.available2024-07-22T08:08:50Z
dc.date.issued2019
dc.description.abstractIntroduction: In daily life biological systems are usually exposed to magnetic field forces at different intensities and frequencies, either directly or indirectly. Despite negative results, the therapeutic use of the low dose magnetic field has been found in recent studies. The effect of magnetic field forces on cochlear cells is not clear in the literature. Objective: In our study, we first applied in vivo pulsed magnetic fields to laboratory rats to investigate the effects on cochlea with distortion product otoacoustic emission test followed by histopathological examinations. Methods: Twelve rats were included in this study, separated into two groups as study group and control group. The rats in the study group were exposed to 40 Hz pulsed magnetic field for 1 h/day for 30 days; the hearing of the rats was controlled by otoacoustic emission test. Also, their cochleas were removed and histochemical examination was performed by Caspase-3, Caspase-9, and TUNEL methods. Results: A statistically significant difference was determined (p < 0.05) when the hearing thresholds of the groups obtained by using 5714 Hz and 8000 Hz stimuli were compared by Kruskal–Wallis test. A significant reaction was observed in the study group, especially in the outer ciliated cells during immunohistochemical examinations by using Caspase-3 and Caspase-9 methods. A significantly positive difference was determined in the study group, especially at the outer ciliated cells and the support cells of the corti organ, when compared to the control group (p < 0.05) by the TUNEL method. Conclusion: According to the results of our study, the very low dose magnetic field, which is considered to be used for therapeutic purposes recently, can cause both auditory function defects and histopathologic damage in cochlear cells. © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
dc.identifier.DOI-ID10.1016/j.bjorl.2018.10.013
dc.identifier.issn18088694
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14555
dc.language.isoEnglish
dc.publisherElsevier Editora Ltda
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectCochlea
dc.subjectElectromagnetic Fields
dc.subjectHair Cells, Auditory, Outer
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStatistics, Nonparametric
dc.subjectcaspase 3
dc.subjectcaspase 9
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectauditory threshold
dc.subjectciliated epithelium cell
dc.subjectcochlea
dc.subjectcontrolled study
dc.subjectCorti organ
dc.subjectdistortion product otoacoustic emission
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectin vivo study
dc.subjectmagnetic field
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectTUNEL assay
dc.subjectvery low dose pulsed magnetic wave
dc.subjectanimal
dc.subjectcochlea
dc.subjectelectromagnetism
dc.subjectnonparametric test
dc.subjectouter hair cell
dc.subjectpathology
dc.subjectspontaneous otoacoustic emission
dc.subjectWistar rat
dc.titleThe effect of very low dose pulsed magnetic waves on cochlea; [Efeito de ondas magnéticas pulsadas de dosagem extremamente baixa na cóclea]
dc.typeArticle

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