Histopathologic effect of chronic use of sildenafil citrate on the choroid & retina in male rats

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dc.contributor.authorVatansever H.S.
dc.contributor.authorKayikcioglu O.
dc.contributor.authorGumus B.
dc.date.accessioned2024-07-22T08:24:45Z
dc.date.available2024-07-22T08:24:45Z
dc.date.issued2003
dc.description.abstractBackground & objectives: Sildenafil citrate is an oral medication used to treat male impotence by the inhibition of phosphodiesterase-5 in the corpus cavernosum and subsequent facilitation of penile erection. Though the ocular side effects of sildenafil have been reported, no information is available on the histopathologic effects of chronic use of sildenafil citrate on the ocular vasculature. The present study was undertaken to study the histopathologic effects of chronic use of sildenafil on the retina and choroid of male rats. Methods: Twelve adult male Wistar rats were used in the study. Six of them were given 8 mg/kg/day sildenafil citrate orally on alternate days, the other six rats were used as control. The animals were sacrificed after 4 wk of treatment, and the eyes were fixed in 10 per cent formalin solution and sectioned after embedding in paraffin. Sections were cut, stained with haematoxylin-eosin (HE) or periodic acid Schiff (PAS) and examined under light microscope. The choroidal capillary diameter was also measured. Results: The choroidal capillaries were more dilated in the sildenafil citrate treated group (mean capillary diameter 3.44 ± 1.68 μm versus the control of 1.78±1.36 μm, P<0.001). The retinal layers and their configuration were unchanged in both the groups. Interpretation & conclusion: Chronic use of sildenafil citrate can cause dilatation and congestion in the choroidal vasculature of male rats.
dc.identifier.issn09715916
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20102
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectChoroid
dc.subjectMale
dc.subjectPhosphodiesterase Inhibitors
dc.subjectPiperazines
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRetina
dc.subjecteosin
dc.subjecthematoxylin
dc.subjectparaffin
dc.subjectperiodic acid
dc.subjectsildenafil
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectblood vessel occlusion
dc.subjectchoroid
dc.subjectchoroid capillary layer
dc.subjectchronic drug administration
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjecthistopathology
dc.subjectmale
dc.subjectmicroscope
dc.subjectnonhuman
dc.subjectrat
dc.subjectretina
dc.subjectretina blood vessel
dc.subjectstaining
dc.subjectvasodilatation
dc.titleHistopathologic effect of chronic use of sildenafil citrate on the choroid & retina in male rats
dc.typeArticle

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