EPISODE OF ACUTE HEMOLYSIS DUE TO UNDIAGNOSED GLUCOSE-6-PHOSPHATE DEHIDROGENASE DEFICIENCY IN AN ADOLESCENT WITH NEWLY DIAGNOSED TYPE 1 DIABETES MELLITUS: CASE REPORT AND REVIEW OF LITERATURE

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dc.contributor.authorGoren T.A.
dc.contributor.authorKilimci D.D.
dc.contributor.authorYigit Y.
dc.contributor.authorYildirim A.T.
dc.contributor.authorGulen H.
dc.contributor.authorErsoy B.
dc.date.accessioned2024-07-22T08:02:56Z
dc.date.available2024-07-22T08:02:56Z
dc.date.issued2023
dc.description.abstractGlucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is common in the community. The most important clinical manifestation of G6PD deficiency is acute hemolytic anemia due to oxidative stressors. Diabetes Mellitus (DM) can precipitate hemolysis in patients with G6PD deficiency. Here, we described a 15-year-old male with newly diagnosed type 1 DM (T1DM) and unknown G6PD deficiency who suffered from hemolytic anemia during normalization of blood glucose. On admission, the patient did not have ketoacidosis. After the patient's blood sugars were regulated with insulin therapy, he presented five days later with hemolytic anemia. The cause of hemolytic anemia was G6PD deficiency. The patient had no previous episodes of hemolysis and had no relevant family history. Hypoglycemia did not occur during blood glucose regulation. The return of blood sugar to normal after a long period of hyperglycemia was thought to be the possible cause of hemolysis. In conclusion, G6PD deficiency should be considered when there is an episode of hemolysis in newly diagnosed children and adolescents with T1DM, especially in the absence of ketoacidosis and hypoglycemia. © 2023, Acta Endocrinologica Foundation. All rights reserved.
dc.identifier.DOI-ID10.4183/aeb.2023.256
dc.identifier.issn18410987
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12061
dc.language.isoEnglish
dc.publisherActa Endocrinologica Foundation
dc.rightsAll Open Access; Green Open Access
dc.subjectbicarbonate
dc.subjectbilirubin
dc.subjectbilirubin glucuronide
dc.subjectC peptide
dc.subjectfosfomycin
dc.subjectglucose
dc.subjectglucose 6 phosphate dehydrogenase
dc.subjecthemoglobin
dc.subjecthemoglobin A1c
dc.subjectinsulin
dc.subjectketone
dc.subjectlong acting insulin
dc.subjectpotassium
dc.subjectshort acting insulin
dc.subjectsodium
dc.subjectabdominal pain
dc.subjectadolescent
dc.subjectArticle
dc.subjectblood gas analysis
dc.subjectcarbon dioxide tension
dc.subjectcase report
dc.subjectclinical article
dc.subjectdehydration
dc.subjectfasting insulin level
dc.subjectfollow up
dc.subjectglucose 6 phosphate dehydrogenase deficiency
dc.subjectglucose blood level
dc.subjecthemolysis
dc.subjecthemolytic anemia
dc.subjecthuman
dc.subjecthyperglycemia
dc.subjectinsulin dependent diabetes mellitus
dc.subjectjaundice
dc.subjectmale
dc.subjectnocturia
dc.subjectpallor
dc.subjectpH
dc.subjectpolydipsia
dc.subjectpolyuria
dc.subjectreticulocyte count
dc.subjectundiagnosed disease
dc.subjecturinalysis
dc.subjecturinary tract infection
dc.titleEPISODE OF ACUTE HEMOLYSIS DUE TO UNDIAGNOSED GLUCOSE-6-PHOSPHATE DEHIDROGENASE DEFICIENCY IN AN ADOLESCENT WITH NEWLY DIAGNOSED TYPE 1 DIABETES MELLITUS: CASE REPORT AND REVIEW OF LITERATURE
dc.typeArticle

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