Out-of-reference range thyroid-stimulating hormone levels in levothyroxine-treated primary hypothyroid patients: A multicenter observational study

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dc.contributor.authorYavuz D.G.
dc.contributor.authorYazici D.
dc.contributor.authorKeskin L.
dc.contributor.authorAtmaca A.
dc.contributor.authorSancak S.
dc.contributor.authorSaraç F.
dc.contributor.authorŞahin I.
dc.contributor.authorDikbaş O.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorYalin S.
dc.contributor.authorUygur M.
dc.contributor.authorYilmaz M.
dc.contributor.authorYirmibeşcik S.
dc.contributor.authorAsmaz Ö.
dc.date.accessioned2024-07-22T08:10:38Z
dc.date.available2024-07-22T08:10:38Z
dc.date.issued2017
dc.description.abstractObjective: Although levothyroxine (LT4) replacement therapy for hypothyroidism has been established as safe, inexpensive and effective, many studies from different countries reported out-of-reference range thyroid-stimulating hormone (TSH) values for the hypothyroid patients under LT4 treatment. The aim of this study was to determine TSH levels of primary hypothyroid patients under LT4 treatment and to assess self-reported compliance with daily LT4 intake in tertiary care centers in Turkey. Design: In this cross-sectional, observational study, adult patients with primary hypothyroidism, receiving LT4 treatment for at least 6 months, were included. The patients were from 12 tertiary care centers in 9 cities of Turkey. TSH and free T4 levels were recorded from patient files and self-reported compliance with daily LT4 intake was assessed by interviewing the subjects at the last visit. Results: A total of 1,755 subjects (46 ± 13 years; F/M: 89.9/10.1%) with primary hypothyroidism were enrolled. Of the hypothyroid subjects, 44.8% had out-of-reference range serum TSH levels. TSH values were over the reference range (TSH > 4 mIU/L) in 26.2% and were under the reference range (TSH < 0.5 mIU/L) in 18.6% of the patients. Total duration of LT4 treatment was 5.9 ± 4.7 years and mean dose was 1.2 ± 0.6 μg/kg/day. Non-compliant patients (31.1%) had higher TSH levels (6.9 ± 16 vs 3.8 ± 0.9 mIU/L, P = 0.01) compared to compliant patients. Conclusion: The results of this study revealed that nearly half of the hypothyroid patients had out-of-reference range serum TSH values, despite under LT4 treatment. Compliance with LT4 treatment seems to be one of the major determinants to reach the target TSH levels in hypothyroid patients. © 2017 Yavuz, Yazici, Keskin, Atmaca, Sancak, Saraç, Şahin, Dikbaş, Hekimsoy, Yalin, Uygur, Yilmaz, Yirmibeşcik and Asmaz.
dc.identifier.DOI-ID10.3389/fendo.2017.00215
dc.identifier.issn16642392
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15319
dc.language.isoEnglish
dc.publisherFrontiers Media S.A.
dc.rightsAll Open Access; Gold Open Access
dc.subjectlevothyroxine
dc.subjectradioactive iodine
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbody mass
dc.subjectchemiluminescence immunoassay
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectcross-sectional study
dc.subjectdose response
dc.subjectfemale
dc.subjectHashimoto disease
dc.subjecthormone substitution
dc.subjecthuman
dc.subjecthyperthyroidism
dc.subjecthypothyroidism
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedication compliance
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectobservational study
dc.subjectradiofrequency ablation
dc.subjectself report
dc.subjecttertiary care center
dc.subjectthyroidectomy
dc.subjectthyrotropin blood level
dc.subjectthyroxine blood level
dc.subjecttoxic goiter
dc.subjecttreatment duration
dc.subjecttreatment response
dc.subjectvery elderly
dc.titleOut-of-reference range thyroid-stimulating hormone levels in levothyroxine-treated primary hypothyroid patients: A multicenter observational study
dc.typeArticle

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