Biological effects of tolerable level chronic boron intake on transcription factors

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dc.contributor.authorOrenay Boyacioglu S.
dc.contributor.authorKorkmaz M.
dc.contributor.authorKahraman E.
dc.contributor.authorYildirim H.
dc.contributor.authorBora S.
dc.contributor.authorAtaman O.Y.
dc.date.accessioned2024-07-22T08:11:17Z
dc.date.available2024-07-22T08:11:17Z
dc.date.issued2017
dc.description.abstractThe mechanism of boron effect on human transcription and translation has not been fully understood. In the current study it was aimed to reveal the role of boron on the expression of certain transcription factors that play key roles in many cellular pathways on human subjects chronically exposed to low amounts of boron. The boron concentrations in drinking water samples were 1.57 ± 0.06 mg/l for boron group while the corresponding value for the control group was 0.016 ± 0.002 mg/l. RNA isolation was performed using PAX gene RNA kit on the blood samples from the subjects. The RNA was then reverse transcribed into cDNA and analyzed using the Human Transcription Factors RT2 Profiler™ PCR Arrays. While the boron amount in urine was detected as 3.56 ± 1.47 mg/day in the boron group, it was 0.72 ± 0.30 mg/day in the control group. Daily boron intake of the boron and control groups were calculated to be 6.98 ± 3.39 and 1.18 ± 0.41 mg/day, respectively. The expression levels of the transcription factor genes were compared between the boron and control groups and no statistically significant difference was detected (P > 0.05). The data suggest that boron intake at 6.98 ± 3.39 mg/day, which is the dose at which beneficial effects might be seen, does not result in toxicity at molecular level since the expression levels of transcription factors are not changed. Although boron intake over this level will seem to increase RNA synthesis, further examination of the topic is needed using new molecular epidemiological data. © 2016 Elsevier GmbH
dc.identifier.DOI-ID10.1016/j.jtemb.2016.06.009
dc.identifier.issn0946672X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15572
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectAdult
dc.subjectBoron
dc.subjectDrinking Water
dc.subjectHumans
dc.subjectMass Spectrometry
dc.subjectTranscription Factors
dc.subjectWater Pollutants, Chemical
dc.subjectboron
dc.subjectcreatinine
dc.subjectdrinking water
dc.subjecttranscription factor
dc.subjectboron
dc.subjecttranscription factor
dc.subjectwater pollutant
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcreatinine clearance
dc.subjectdietary reference intake
dc.subjectgene expression
dc.subjecthuman
dc.subjectlong term exposure
dc.subjectpriority journal
dc.subjectRNA synthesis
dc.subjectTurk (people)
dc.subjecturine level
dc.subjectanalysis
dc.subjectbiosynthesis
dc.subjectchemistry
dc.subjectgenetics
dc.subjectmass spectrometry
dc.subjectwater pollutant
dc.titleBiological effects of tolerable level chronic boron intake on transcription factors
dc.typeArticle

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