Frequency of TP53 codon72 polymorphism in cases with colon cancer

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dc.contributor.authorOnrat S.T.
dc.contributor.authorEllidokuz E.
dc.contributor.authorKüpelioǧlu A.
dc.contributor.authorDurhan E.
dc.date.accessioned2024-07-22T08:21:32Z
dc.date.available2024-07-22T08:21:32Z
dc.date.issued2009
dc.description.abstractRecent studies indicated that the Arg allele is preferentially mutated and retained in various human cancers arising in Pro/Arg heterozygotes and it may be an important biomarker in colon cancer prognosis. In this study, DNA was isolated from paraffine-embedded colon tumor tissue samples of 35 cases diagnosed as colon carcinoma. We have observed PCR-RFLP genotyping for the codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene. In this study, we detected that TP53 codon 72 polymorphism was present in 27 (77.1%) of 35 cases enrolled into the study. In 14 (51.9%) cases Arg/Arg, 11 (40.7%) cases Arg/Pro and 2 (7.4%) cases Pro/Pro genotype frequencies were found. In 8 (22.9%) cases DNA isolation were not obtained. Our results point out that individuals homozygous for the Arg allele have higher frequency than other alleles and that colon cancer may be related to Arg allele frequency.
dc.identifier.issn10193103
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18663
dc.language.isoEnglish
dc.subjectarginine
dc.subjectDNA
dc.subjectproline
dc.subjectprotein p53
dc.subjectadult
dc.subjectaged
dc.subjectallele
dc.subjectarticle
dc.subjectcancer risk
dc.subjectcancer tissue
dc.subjectclinical article
dc.subjectcodon
dc.subjectcolon carcinoma
dc.subjectcontrolled study
dc.subjectDNA isolation
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjecthomozygosity
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.titleFrequency of TP53 codon72 polymorphism in cases with colon cancer
dc.typeArticle

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