The effects of fibroblast growth factor-2 blocking on development of chick cervical vertebra and relationship with oxidative stress and apoptosis; [Fibroblast growth faktör-2 bloklamasi{dotless}ni{dotless}n tavuk servikal omurlari{dotless} üzerindeki etkisi ve oksidatif stres ve apoptozis ile i̇lişkisi]

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dc.contributor.authorDuransoy Y.K.
dc.contributor.authorŞimşek T.
dc.contributor.authorÖztürk F.
dc.contributor.authorMete M.
dc.contributor.authorTuǧlu M.I.
dc.contributor.authorSelçuki M.
dc.date.accessioned2024-07-22T08:17:17Z
dc.date.available2024-07-22T08:17:17Z
dc.date.issued2014
dc.description.abstractFibroblast growth factor (FGF) plays a role in the development of bone and cartilage. FGF-2 is a member of this family and blocking of FGF-2 affects the bone development. In this study, effects of FGF-2 blocking on the formation of vertebrae in chick embryos before ossifications and orientation of cervical vertebrae were investigated with histological examinations. In this study, anti-FGF-2 was performed to chick embryos at E4th and E10th days. Samples were taken in E15th days and changes in the cervical spine were evaluated as histochemically (with hematoxylin-eosin, Alizarin red, Masson's trichrome staining) and immunohistochemically (with iNOS, eNOS and TUNEL). Also changings were evaluated by morphometric analysis. In macroscopic examination of the cervical vertebrae significant difference was not detected. But in histochemical staining, defects were observed in cartilage and ossification process. Increasing in oxidative stress was demonstrated by iNOS and eNOS. Also apoptosis which was represented by tunnel was found to be increased. FGF-2 blocking affects the ossification process in the cervical spine by inducing oxidative stress and apoptosis which results with cell death.
dc.identifier.issn13001817
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17017
dc.language.isoEnglish
dc.publisherEge University Press
dc.subjectanti fibroblast growth factor 2
dc.subjectfibroblast growth factor 2
dc.subjectunclassified drug
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcartilage
dc.subjectcell death
dc.subjectcervical spine
dc.subjectcontrolled study
dc.subjectDNA fragmentation
dc.subjectdomestic fowl
dc.subjectembryo
dc.subjectimmunohistochemistry
dc.subjectmorphometrics
dc.subjectnick end labeling
dc.subjectnonhuman
dc.subjectossification
dc.subjectoxidative stress
dc.subjectstereomicroscopy
dc.titleThe effects of fibroblast growth factor-2 blocking on development of chick cervical vertebra and relationship with oxidative stress and apoptosis; [Fibroblast growth faktör-2 bloklamasi{dotless}ni{dotless}n tavuk servikal omurlari{dotless} üzerindeki etkisi ve oksidatif stres ve apoptozis ile i̇lişkisi]
dc.typeArticle

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