The level Pro-inflammatory and Anti-Inflammatory Biomarkers in patients with chronic mechanical low back pain under Pulse radiofrequency therapy
| dc.contributor.author | Tekin I. | |
| dc.contributor.author | Kosova F. | |
| dc.date.accessioned | 2024-07-22T08:04:30Z | |
| dc.date.available | 2024-07-22T08:04:30Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Low back pain is a frequent and recurrent condition, often with a non-specific cause. Conventional treatment methods are generally insufficient in the treatment of chronic low back pain. The aim of the study was to estimate the level of IFN, IL-1, IL-6 (proinflammatory), IL-10, IL-4 (anti-inflammatory) and VEGF proteins in the serum of patients with chronic mechanical low back pain under Pulse radiofrequency (PRF) therapy. The study was carried out on 40 patients 20-60 years old, diagnosed with chronic low back pain for at least 4 months, primary complaint on lumbosacral low back pain, pain intensity VAS (visual analog scale) score of 5 and above, not responding well to conservative treatment (analgesic drugs, physiotherapy, etc.). Therapeutic Radiofrequency applications were carried out with an RF generator (RFG 3C Plus, Radionics). Blood samples were taken 1 day before interventional treatment (control), then 1 day (group1) and 15 days (group 2) after. The serum level of IFN, IL-1, IL-6, IL-10, IL-4 and VEGF l was analyzed with ELISA test. It was shown that as a result of PRF treatment the level of IL-1 was decreased while the levels of IL-4 and IL-6 were increased. It was concluded that the increase in serum levels of proinflammatory cytokines may be cor-related with the severity of pain and that the increase in the level of anti-inflammatory cytokines reduces pain by reducing inflammation. © 2022, Palladin Institute of Biochemistry of the NASU. All rights reserved. | |
| dc.identifier.DOI-ID | 10.15407/ubj94.03.059 | |
| dc.identifier.issn | 24094943 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12729 | |
| dc.language.iso | English | |
| dc.publisher | Palladin Institute of Biochemistry of the NASU | |
| dc.rights | All Open Access; Gold Open Access | |
| dc.title | The level Pro-inflammatory and Anti-Inflammatory Biomarkers in patients with chronic mechanical low back pain under Pulse radiofrequency therapy | |
| dc.type | Article |