Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis

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dc.contributor.authorTurkoglu O.
dc.contributor.authorEmingil G.
dc.contributor.authorEren G.
dc.contributor.authorAtmaca H.
dc.contributor.authorKutukculer N.
dc.contributor.authorAtilla G.
dc.date.accessioned2024-07-22T08:10:58Z
dc.date.available2024-07-22T08:10:58Z
dc.date.issued2017
dc.description.abstractObjectives: hCAP18/LL-37 is an endogenous antibiotic having a role in innate immunity. The aim of the present study was to evaluate serum and gingival crevicular fluid (GCF) hCAP18/LL-37 levels in patients with generalized aggressive periodontitis (G-AgP). Materials and methods: Twenty-six G-AgP patients, 24 gingivitis patients, and 25 healthy subjects were included in this study. Periodontal parameters including probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. GCF and serum hCAP18/LL-37 levels were analyzed by enzyme-linked immunosorbent assay. Results: GCF hCAP18/LL-37 level was significantly higher in G-AgP compared to others (p = 0.038, p < 0.001). Gingivitis patients had significantly higher GCF hCAP18/LL-37 levels than controls (p < 0.001). No significant differences were observed in serum hCAP18/LL-37 levels among the study groups (p = 0.524). While there were positive correlations between GCF hCAP18/LL-37 levels and periodontal parameters of sampling sites (p < 0.005), no significant correlation was observed between serum hCAP18/LL-37 levels and whole-mouth periodontal parameters (p > 0.05). Conclusion: Increased levels of GCF hCAP18/LL-37 in G-AgP might show that it is abundantly expressed in the presence of periodontal tissue destruction. Serum hCAP18/LL-37 levels do not seem to be related with the presence of G-AgP. Clinical relevance: hCAP18/LL-37 antimicrobial peptide might be associated with periodontal tissue destruction in the presence of aggressive periodontitis. © 2016, Springer-Verlag Berlin Heidelberg.
dc.identifier.DOI-ID10.1007/s00784-016-1834-z
dc.identifier.issn14326981
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15468
dc.language.isoEnglish
dc.publisherSpringer Verlag
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAggressive Periodontitis
dc.subjectAntimicrobial Cationic Peptides
dc.subjectCase-Control Studies
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectGingival Crevicular Fluid
dc.subjectHumans
dc.subjectMale
dc.subjectantimicrobial cationic peptide
dc.subjectCAP18 lipopolysaccharide-binding protein
dc.subjectadolescent
dc.subjectadult
dc.subjectaggressive periodontitis
dc.subjectcase control study
dc.subjectclassification
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgingivitis
dc.subjecthuman
dc.subjectimmunology
dc.subjectmale
dc.titleGingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis
dc.typeArticle

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