Postoperative beneficial effects of esmolol in treated hypertensive patients undergoing laparoscopic cholecystectomy

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dc.contributor.authorOzturk T.
dc.contributor.authorKaya H.
dc.contributor.authorAran G.
dc.contributor.authorAksun M.
dc.contributor.authorSavaci S.
dc.date.accessioned2024-07-22T08:22:34Z
dc.date.available2024-07-22T08:22:34Z
dc.date.issued2008
dc.description.abstractBackground: In an attempt to decrease haemodynamic instability and early postoperative complications such as nausea, vomiting, and pain, esmolol was added to the routine alfentanil infusion of patients with treated hypertension undergoing laparoscopic cholecystectomy. Methods: Forty consecutive ASA class II patients with controlled hypertension about to undergo laparoscopic cholecystectomy were randomized into two groups: an esmolol group (Group E, n=20) was given a 1 mg kg-1 bolus of esmolol and a placebo group (Group P, n=20) was given an identical volume of Ringer's lactate. The rate of esmolol infusion was adjusted to keep the heart rate between 65 and 75 beats min-1 and was 5-10 μg kg-1 min-1 throughout the procedure. After operation, patients reported their nausea using a four-point scale. Results: Esmolol had an opioid-sparing effect intraoperatively (P=0.001). Postoperative requirements for antiemetics were significantly less in the esmolol group, with no antiemetics given to eight patients. In the placebo group, however, all patients required at least one dose of antiemetic (P=0.007). The frequency of PONV did not correlate to the amounts of alfentanil, propofol, postoperative antiemetics consumed, or to female gender, non-smoking status, and history of PONV or motion sickness. Postoperative analgesic consumption in Group E was significantly lower than in Group P (P=0.012). Conclusions: Esmolol had an opioid-sparing effect in the intraoperative and immediate postoperative period in hypertensive patients undergoing laparoscopy. When combined with alfentanil, it was more effective than placebo in decreasing early PONV. © The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved.
dc.identifier.DOI-ID10.1093/bja/aem333
dc.identifier.issn00070912
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19144
dc.language.isoEnglish
dc.publisherOxford University Press
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdrenergic beta-Antagonists
dc.subjectAdult
dc.subjectAged
dc.subjectAlfentanil
dc.subjectAnesthetics, Intravenous
dc.subjectAntiemetics
dc.subjectCholecystectomy, Laparoscopic
dc.subjectDouble-Blind Method
dc.subjectDrug Administration Schedule
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPain, Postoperative
dc.subjectPostoperative Nausea and Vomiting
dc.subjectPropanolamines
dc.subjectSeverity of Illness Index
dc.subjectalfentanil
dc.subjectantiemetic agent
dc.subjectesmolol
dc.subjectpropofol
dc.subjectRinger lactate solution
dc.subjectalfentanil
dc.subjectantiemetic agent
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectesmolol
dc.subjectintravenous anesthetic agent
dc.subjectpropanolamine derivative
dc.subjectadult
dc.subjectarticle
dc.subjectcholecystectomy
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdrug dose titration
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug infusion
dc.subjectdrug use
dc.subjectfemale
dc.subjectgender
dc.subjectheart rate
dc.subjecthuman
dc.subjecthypertension
dc.subjectintraoperative period
dc.subjectmale
dc.subjectmotion sickness
dc.subjectpatient coding
dc.subjectpostoperative nausea and vomiting
dc.subjectpostoperative period
dc.subjectpriority journal
dc.subjectrandomization
dc.subjectrating scale
dc.subjectsmoking
dc.subjectaged
dc.subjectcholecystectomy
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectdouble blind procedure
dc.subjectdrug administration
dc.subjecthospitalization
dc.subjecthypertension
dc.subjectmiddle aged
dc.subjectpostoperative nausea and vomiting
dc.subjectpostoperative pain
dc.subjectrandomized controlled trial
dc.titlePostoperative beneficial effects of esmolol in treated hypertensive patients undergoing laparoscopic cholecystectomy
dc.typeArticle

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