Follow up of renal outcomes in children with solitary kidney

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dc.contributor.authorAkyol Onder E.N.
dc.contributor.authorYilmaz O.
dc.contributor.authorTaneli C.
dc.contributor.authorErtan P.
dc.date.accessioned2024-07-22T08:03:33Z
dc.date.available2024-07-22T08:03:33Z
dc.date.issued2023
dc.description.abstractBackground: Solitary kidney (SK) affects 1/1000 people worldwide, and there are controversies concerning renal outcomes in these patients. This study aimed to investigate clinical findings and renal outcomes in children with SK and to compare the results for congenital (CSK) and acquired SK (ASK) groups. Methods: The study included patients that presented to our pediatric nephrology department with SK between January 2010 and January 2021. Demographic and clinical data were recorded retrospectively. Results: Of the 101 patients with SK, 71 had CSK (55 had unilateral renal agenesis and 16 had a multicystic dysplastic kidney) and 30 had ASK (17 had previously undergone unilateral nephrectomy due to a renal tumor and 13 had urological structural anomalies). There were nine patients (9%) with renal injury. The serum uric acid level was significantly higher and the estimated glomerular filtration rate was significantly lower in the patients with ASK compared with those with CSK (p = 0.005 and p < 0.001, respectively). There was a positive correlation between renal injury and the uric acid level (p < 0.001, r = 0.45). Conclusion: In addition to the management of blood pressure and proteinuria, it is important to control uric acid levels in patients with SK, especially those with ASK, to prevent renal injury. The ASK group has a greater risk of renal injury than the CSK group. There is a need for new markers to predict early stage renal damage in SK. © 2023 Japan Pediatric Society.
dc.identifier.DOI-ID10.1111/ped.15488
dc.identifier.issn13288067
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12341
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectChild
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectKidney
dc.subjectRetrospective Studies
dc.subjectSolitary Kidney
dc.subjectUric Acid
dc.subjectangiotensinogen
dc.subjectcreatinine
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectsuccimer
dc.subjecturic acid
dc.subjecturic acid
dc.subjectadolescent
dc.subjectArticle
dc.subjectblood pressure monitoring
dc.subjectbody mass
dc.subjectchild
dc.subjectclinical outcome
dc.subjectcystourethrography
dc.subjectdemography
dc.subjectdiastolic blood pressure
dc.subjectechography
dc.subjectestimated glomerular filtration rate
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthydronephrosis
dc.subjectkidney agenesis
dc.subjectkidney hypertrophy
dc.subjectkidney injury
dc.subjectkidney tumor
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmulticystic dysplastic kidney
dc.subjectnephrology
dc.subjectoutcome assessment
dc.subjectproteinuria
dc.subjectretrospective study
dc.subjectscintigraphy
dc.subjectsolitary kidney
dc.subjectsystolic blood pressure
dc.subjecturic acid blood level
dc.subjecturinary tract infection
dc.subjectcomplication
dc.subjectfollow up
dc.subjectkidney
dc.subjectsolitary kidney
dc.titleFollow up of renal outcomes in children with solitary kidney
dc.typeArticle

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