Antenatal administration of granulocyte-macrophage colony-stimulating factor increases fetal lung maturation and endothelial nitric oxide synthase expression in the fetal rat lung

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dc.contributor.authorBaytur Y.B.
dc.contributor.authorOzbilgin K.
dc.contributor.authorYuksel H.
dc.contributor.authorKose C.
dc.date.accessioned2024-07-22T08:22:31Z
dc.date.available2024-07-22T08:22:31Z
dc.date.issued2008
dc.description.abstractObjectives: We investigated how maternal administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) induced fetal lung maturation compared with dexamethasone and whether maternal administration of GM-CSF and dexamethasone influenced the fetal lung eNOS expression. Study design: Thirty pregnant rats were divided into three groups of 10 rats each to receive GM-CSF, dexamethasone or saline solution at 16 days of gestation. Lung maturation using bronchial area and immunohistochemical lung airway epithelium and the vascular endothelial eNOS expression, using H Scores, were evaluated at 18 and 20 days of gestation. The statistical analysis was done with the Kruskal-Wallis test for comparisons of more than two groups and the Mann-Whitney U-test as a post hoc test using SPSS for windows release 10.0. Values of p > 0, 0.05 were considered significant. Results: On the 20th day of gestation both GM-CSF and dexamethasone injections caused a significant increase in fetal lung bronchial area, as compared with the controls (24.9%, 36.8%, 13.4%, respectively, p = 0.001). eNOS immunoreactivity was observed in the endothelium of large pulmonary vessels and large and small airway epithelium on the 18th and 20th day of gestation. Maternal GM-CSF and dexamethasone increased lung eNOS expression in the airway epithelium when compared to controls. Conclusion: Maternal administration of GM-CSF induced fetal lung maturation and this effect may be mediated, at least partly, by an increase in the eNOS expression. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.ejogrb.2007.03.010
dc.identifier.issn03012115
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19110
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectdexamethasone
dc.subjectendothelial nitric oxide synthase
dc.subjectrecombinant granulocyte macrophage colony stimulating factor
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectbronchus
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfetus lung maturation
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectKruskal Wallis test
dc.subjectlung alveolus epithelium
dc.subjectlung blood vessel
dc.subjectnonhuman
dc.subjectpregnancy
dc.subjectprenatal care
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrank sum test
dc.subjectrat
dc.subjectsingle drug dose
dc.titleAntenatal administration of granulocyte-macrophage colony-stimulating factor increases fetal lung maturation and endothelial nitric oxide synthase expression in the fetal rat lung
dc.typeArticle

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