Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature
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Date
2022
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Abstract
Introduction: Episodic ataxia is a clinical condition characterized by episodes of balance and coordination problems that last minutes to hours. It can be inherited or sporadic, and it can be seen sporadically in epilepsy, basilar migraine, multiple sclerosis, vertebrobasilar ischaemia, and labyrinth diseases. Methods: In this article, we present a case of a patient who had a coincidental occurrence of episodic ataxia type 2 (EA2) and multiple sclerosis (MS) Results: The patient who had a previously unidentified heterozygous mutation in the calcium voltage-gated channel subunit alpha 1 A gene (CACNA1A). Conclusion: There is no publication in the literature reporting the co-occurrence of MS and EA2. This combination may be coincidental in this patient, or it may be a relationship that has not yet been scientifically revealed. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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Ataxia , Calcium Channels , Humans , Migraine with Aura , Multiple Sclerosis , acetazolamide , calcium voltage gated channel subunit alpha 1a , carbamazepine , glatiramer , immunoglobulin G , methylprednisolone , oligoclonal band , unclassified drug , valproic acid , voltage gated calcium channel , calcium channel , abdominal pain , Article , ataxia , ataxic gait , blurred vision , case report , caudate nucleus , cerebrospinal fluid analysis , cervical spinal cord , clinical article , corticosteroid therapy , diplopia , dizziness , drug dose reduction , drug pulse therapy , drug withdrawal , dysarthria , electroencephalogram , electroencephalography , epilepsy , epileptic discharge , episodic ataxia type 2 , exon , faintness , family history , febrile convulsion , female , fever , focal epilepsy , follow up , frameshift mutation , gaze paralysis , gene sequence , head movement , hematuria , hemiparesis , heterozygote , Hoffmann reflex , hot flush , human , hyporeflexia , intron , iron deficiency anemia , learning disorder , limb weakness , mesencephalon , metabolic acidosis , multiple sclerosis , nausea , nuclear magnetic resonance imaging , nystagmus , paternal inheritance , perception disorder , seizure , slurred speech , spastic gait , spasticity , speech disorder , stop codon , thoracic spinal cord , vertigo , visual acuity , visual evoked potential , vomiting , white matter , ataxia , complication , genetics , migraine with aura , multiple sclerosis